Cai, XingguangXingguangCaiJavor, SachaSachaJavorGan, Bee HaBee HaGanKöhler, ThiloThiloKöhlerReymond, Jean-LouisJean-LouisReymond0000-0003-2724-29422024-10-072024-10-072021-05-05https://boris-portal.unibe.ch/handle/20.500.12422/58863pH-activity profiling reveals that antimicrobial peptide dendrimers (AMPDs) kill Klebsiella pneumoniae and Methicillin-resistant Staphylococcus aureus (MRSA) at pH = 8.0, against which they are inactive at pH = 7.4, due to stronger electrostatic binding to bacterial cells at higher pH. A similar effect occurs with polymyxin B and might be general for polycationic antimicrobials.en500 - Science::570 - Life sciences; biology500 - Science::540 - Chemistryarticle10.48350/1630023397296410.1039/D1CC01838H