Förger, FraukeFraukeFörgerOestensen, Monika ElisabethMonika ElisabethOestensen2024-10-102024-10-102010https://boris-portal.unibe.ch/handle/20.500.12422/72370During pregnancy, most patients with rheumatoid arthritis (RA) experience spontaneous improvement of their disease activity. Among the soluble candidates that have been investigated in search for the most relevant disease-remitting factor are the galactosylation levels of immunoglobulin G (IgG). In RA, a higher percentage of IgG lacking the terminal galactose residues, thought to play a pro-inflammatory role, is found. During pregnancy, however, IgG galactosylation levels increase and correlate with improved disease activity. The question remains whether the increase in IgG galactosylation during pregnancy is a mere epiphenomenon or a true remission-inducing factor.enarticle10.7892/boris.16542023644800027801270000810.1186/ar2919