Azzi, AAAzziBoscoboinik, DDBoscoboinikClément, SSClémentOzer, N KN KOzerRicciarelli, RRRicciarelliStocker, AchimAchimStocker0000-0001-6862-7887Tasinato, AATasinatoSirikçi, OOSirikçi2024-09-022024-09-021997https://boris-portal.unibe.ch/handle/20.500.12422/34854alpha-Tocopherol but not beta-tocopherol, activates protein phosphatase 2A, decreases protein kinase C activity and attenuates smooth muscle cell proliferation at physiological concentrations. beta-Tocopherol prevents the effects of alpha-tocopherol. Inhibition of protein kinase C alpha, but not of the other isoforms, by the inhibitor Gö6976 prevents the effect of alpha-tocopherol. Protein kinase C alpha, immunoprecipitated from alpha-tocopherol treated cells, is less phosphorylated and inactive. It is proposed that the specific activation of protein phosphatase 2A by alpha-tocopherol results in dephosphorylation and inactivation of protein kinase C alpha. Finally, this cascade of events leads to smooth muscle cell proliferation inhibition.en500 - Science::570 - Life sciences; biology500 - Science::540 - Chemistryarticle9350476