Cottagnoud, PPCottagnoudGerber, CMCMGerberAcosta, FFAcostaCottagnoud, MMCottagnoudNeftel, KKNeftelTäuber, Martin G.Martin G.Täuber2024-10-132024-10-132000https://boris-portal.unibe.ch/handle/20.500.12422/99239Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 x and 10 x MIC).enarticle10.7892/boris.257451110241800016604700001710.1093/jac/46.6.981