Aebi, JohannesJohannesAebiAtz, KennethKennethAtzAmetamey, Simon MSimon MAmetameyBenz, JörgJörgBenzBlaising, JulieJulieBlaisingButini, StefaniaStefaniaButiniCampiani, GiuseppeGiuseppeCampianiCarreira, Erick MErick MCarreiraCollin, LudovicLudovicCollinDe Lago, EvaEvaDe LagoGazzi, ThaisThaisGazziGertsch, JürgJürgGertschGobbi, LucaLucaGobbiGuba, WolfgangWolfgangGubaFernández-Ruiz, JavierJavierFernández-RuizFingerle, JürgenJürgenFingerleHaider, AhmedAhmedHaiderHe, YingfangYingfangHeHeitman, Laura HLaura HHeitmanHoner, MichaelMichaelHonerHunziker, DanielDanielHunzikerKuhn, BerndBerndKuhnMaccarrone, MauroMauroMaccarroneMärki, Hans PeterHans PeterMärkiMartin, Rainer ERainer EMartinMohr, PeterPeterMohrMu, LinjingLinjingMuNazaré, MarcMarcNazaréNippa, David FDavid FNippaOddi, SergioSergioOddiO'Hara, FionnFionnO'HaraPacher, PalPalPacherRomero, JulianJulianRomeroRöver, StephanStephanRöverRufer, Arne CArne CRuferSchibli, RogerRogerSchibliSchneider, GisbertGisbertSchneiderStepan, Antonia FAntonia FStepanSykes, David ADavid ASykesUllmer, ChristophChristophUllmerVan der Stelt, MarioMarioVan der SteltVeprintsev, Dmitry BDmitry BVeprintsevWittwer, Matthias BMatthias BWittwerGrether, UweUweGrether2024-10-022024-10-022024-08-21https://boris-portal.unibe.ch/handle/20.500.12422/47953The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating key functions within the central nervous and immune systems. Given its therapeutic significance, we have launched a series of drug discovery endeavors aimed at ECS targets, including peroxisome proliferator-activated receptors (PPARs), cannabinoid receptors types 1 (CB1R) and 2 (CB2R), and monoacylglycerol lipase (MAGL), addressing a wide array of medical needs. The pursuit of new therapeutic agents has been enhanced by the creation of specialized labeled chemical probes, which aid in target localization, mechanistic studies, assay development, and the establishment of biomarkers for target engagement. By fusing medicinal chemistry with chemical biology in a comprehensive, translational end-to-end drug discovery strategy, we have expedited the development of novel therapeutics. Additionally, this strategy promises to foster highly productive partnerships between industry and academia, as will be illustrated through various examples.enAcademia-industry collaborationCB1RCB2REndocannabinoid systemLabeled chemical probeMAGLPPARarticle10.48620/84423922184510.2533/chimia.2024.499