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HRahul HRahangdaleRamakrishnan, PankajavalliPankajavalliRamakrishnanRomero, Jose RafaelJose RafaelRomeroRost, NataliaNataliaRostRothstein, AaronAaronRothsteinRuland, SeanSeanRulandShah, RuchirRuchirShahSharma, MalveekaMalveekaSharmaSilver, BrianBrianSilverSimmons, MarcMarcSimmonsSingh, AbhishekAbhishekSinghStarosciak, Amy KAmy KStarosciakStrasser, Sheryl LSheryl LStrasserSzeder, ViktorViktorSzederTeleb, MohamedMohamedTelebTsai, Jenny PJenny PTsaiVoetsch, BarbaraBarbaraVoetschBalaguera, OscarOscarBalagueraPujol Lereis, Virginia AVirginia APujol LereisLuraschi, AdrianaAdrianaLuraschiAlmeida, Marcele SchettiniMarcele SchettiniAlmeidaCardoso, Fabricio BuchdidFabricio BuchdidCardosoConforto, AdrianaAdrianaConfortoDe Deus Silva, LeonardoLeonardoDe Deus SilvaGiacomini, Luidia VarroneLuidia VarroneGiacominiLima, Fabricio OliveiraFabricio OliveiraLimaLongo, Alexandre LAlexandre LLongoMagalhães, Pedro ScPedro ScMagalhãesMartins, Rodrigo TargaRodrigo TargaMartinsMont'alverne, FranciscoFranciscoMont'alverneMora Cuervo, Daissy LilianaDaissy LilianaMora CuervoRebello, Leticia CostaLeticia CostaRebelloValler, LeniseLeniseVallerZetola, Viviane FlumignanViviane FlumignanZetolaLavados, Pablo MPablo MLavadosNavia, VictorVictorNaviaOlavarría, Verónica VVerónica VOlavarríaAlmeida Toro, Juan ManuelJuan ManuelAlmeida ToroRicardo Amaya, Pablo FelipePablo FelipeRicardo AmayaBayona, HernanHernanBayonaCorredor-Quintero, Angel BasilioAngel BasilioCorredor-QuinteroRivera Ordonez, Carlos EduardoCarlos EduardoRivera OrdonezMantilla Barbosa, Diana KatherineDiana KatherineMantilla BarbosaLara, OsvaldoOsvaldoLaraPatiño, Mauricio RMauricio RPatiñoDiaz Escobar, Luis FernandoLuis FernandoDiaz EscobarDejesus Melgarejo Farina, Donoband EdsonDonoband EdsonDejesus Melgarejo FarinaVillamayor, Analia CardozoAnalia CardozoVillamayorZelaya Zarza, Adolfo JavierAdolfo JavierZelaya ZarzaBarrientos Iman, Danny MoisesDanny MoisesBarrientos ImanKadota, Liliana RodriguezLiliana RodriguezKadotaCampbell, BruceBruceCampbellHankey, Graeme JGraeme JHankeyHair, CaseyCaseyHairKleinig, TimothyTimothyKleinigMa, AliceAliceMaMartins, Rodrigo TomaziniRodrigo TomaziniMartinsSahathevan, RameshRameshSahathevanThijs, VincentVincentThijsSalazar, DanielDanielSalazarYuan-Hao Wu, TeddyTeddyYuan-Hao WuHaussen, Diogo CDiogo CHaussenLiebeskind, DavidDavidLiebeskindYavagal, DileepDileepYavagalJovin, Tudor GTudor GJovinZaidat, Osama OOsama OZaidatNguyen, Thanh NThanh NNguyen2024-09-022024-09-022021-06-08https://boris-portal.unibe.ch/handle/20.500.12422/41901OBJECTIVE The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. METHODS We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases. RESULTS There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p<0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95%CI, -13.8 to -12.7, p<0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95%CI, -13.7 to -10.3, p=0.001). Recovery of stroke hospitalization volume (9.5%, 95%CI 9.2-9.8, p<0.0001) was noted over the two later (May, June) versus the two earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.3% (1,722/52,026) of all stroke admissions. CONCLUSIONS The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.en600 - Technology::610 - Medicine & healtharticle10.48350/1559013376699710.1212/WNL.0000000000011885