Chan, Andrew Hao-KuangAndrew Hao-KuangChanCutter, GaryGaryCutterFox, Robert JRobert JFoxXiao, JamesJamesXiaoLewin, James BJames BLewinEdwards, Michael RMichael REdwards2024-10-252024-10-252017-06https://boris-portal.unibe.ch/handle/20.500.12422/153833AIM Using matching-adjusted indirect comparison, we compared efficacy outcomes in patients with relapsing-remitting multiple sclerosis treated with delayed-release dimethyl fumarate (DMF) or glatiramer acetate (GA). MATERIALS & METHODS An indirect comparison of DMF (patient-level data) and GA (aggregate data) was conducted, with average baseline characteristics of DMF patients weighted to match those for GA patients. Direct comparison of DMF and GA was conducted in CONFIRM. Final results pooled the indirect and direct comparisons using meta-analysis. RESULTS After matching, baseline characteristics were balanced between DMF and GA patients. Compared with GA, efficacy was significantly in favor of DMF as measured by annualized relapse rate (rate ratio: 0.76; 95% CI: 0.57-1.00; p = 0.0474) and 12-week confirmed disability progression (risk ratio: 0.59; 95% CI: 0.46-0.76; p < 0.0001). CONCLUSION DMF demonstrated superior clinical efficacy versus GA.encomparative effectiveness delayed-release dimethyl fumarate glatiramer acetate multiple sclerosis600 - Technology::610 - Medicine & healtharticle10.7892/boris.1021062835024110.2217/cer-2016-0085