Pattaro, CristianCristianPattaroTeumer, AlexanderAlexanderTeumerGorski, MathiasMathiasGorskiChu, Audrey YAudrey YChuLi, ManManLiMijatovic, VladanVladanMijatovicGarnaas, MaijaMaijaGarnaasTin, AdrienneAdrienneTinSorice, RossellaRossellaSoriceLi, YongYongLiTaliun, DanielDanielTaliunOlden, MatthiasMatthiasOldenFoster, MeredithMeredithFosterYang, QiongQiongYangChen, Ming-HueiMing-HueiChenPers, Tune HTune HPersJohnson, Andrew DAndrew DJohnsonKo, Yi-AnYi-AnKoFuchsberger, ChristianChristianFuchsbergerTayo, BamideleBamideleTayoNalls, MichaelMichaelNallsFeitosa, Mary FMary FFeitosaIsaacs, AaronAaronIsaacsDehghan, AbbasAbbasDehghand'Adamo, PioPiod'AdamoAdeyemo, AdebowaleAdebowaleAdeyemoDieffenbach, Aida KarinaAida KarinaDieffenbachZonderman, Alan BAlan BZondermanNolte, Ilja MIlja MNoltevan der Most, Peter JPeter Jvan der MostWright, Alan FAlan FWrightShuldiner, Alan RAlan RShuldinerMorrison, Alanna CAlanna CMorrisonHofman, AlbertAlbertHofmanSmith, Albert VAlbert VSmithDreisbach, Albert WAlbert WDreisbachFranke, AndreAndreFrankeUitterlinden, Andre GAndre GUitterlindenMetspalu, AndresAndresMetspaluTonjes, AnkeAnkeTonjesLupo, AntonioAntonioLupoRobino, AntoniettaAntoniettaRobinoJohansson, ÅsaÅsaJohanssonDemirkan, AyseAyseDemirkanKollerits, BarbaraBarbaraKolleritsFreedman, Barry IBarry IFreedmanPonte, BelenBelenPonteOostra, Ben ABen AOostraPaulweber, BernhardBernhardPaulweberKrämer, Bernhard KBernhard KKrämerMitchell, Braxton DBraxton DMitchellBuckley, Brendan MBrendan MBuckleyPeralta, Carmen ACarmen APeraltaHayward, CarolineCarolineHaywardHelmer, CatherineCatherineHelmerRotimi, Charles NCharles NRotimiShaffer, Christian MChristian MShafferMüller, ChristianChristianMüllerSala, CinziaCinziaSalavan Duijn, Cornelia MCornelia Mvan DuijnSaint-Pierre, AudeAudeSaint-PierreAckermann, DanielDanielAckermannShriner, DanielDanielShrinerRuggiero, DanielaDanielaRuggieroToniolo, DanielaDanielaTonioloLu, YingchangYingchangLuCusi, DanieleDanieleCusiCzamara, DarinaDarinaCzamaraEllinghaus, DavidDavidEllinghausSiscovick, David SDavid SSiscovickRuderfer, DouglasDouglasRuderferGieger, ChristianChristianGiegerGrallert, HaraldHaraldGrallertRochtchina, ElenaElenaRochtchinaAtkinson, Elizabeth JElizabeth JAtkinsonHolliday, Elizabeth GElizabeth GHollidayBoerwinkle, EricEricBoerwinkleSalvi, ErikaErikaSalviBottinger, Erwin PErwin PBottingerMurgia, FedericoFedericoMurgiaRivadeneira, FernandoFernandoRivadeneiraErnst, FlorianFlorianErnstKronenberg, FlorianFlorianKronenbergHu, Frank BFrank BHuNavis, Gerjan JGerjan JNavisCurhan, Gary CGary CCurhanEhret, George BGeorge BEhretHomuth, GeorgGeorgHomuthCoassin, StefanStefanCoassinThun, Gian-AndriGian-AndriThunPistis, GiorgioGiorgioPistisGambaro, GiovanniGiovanniGambaroMalerba, GiovanniGiovanniMalerbaMontgomery, Grant WGrant WMontgomeryEiriksdottir, GudnyGudnyEiriksdottirJacobs, GunnarGunnarJacobsLi, GuoGuoLiWichmann, H-ErichH-ErichWichmannCampbell, HarryHarryCampbellSchmidt, HelenaHelenaSchmidtWallaschofski, HenriHenriWallaschofskiVölzke, HenryHenryVölzkeBrenner, HermannHermannBrennerKroemer, Heyo KHeyo KKroemerKramer, HollyHollyKramerLin, HonghuangHonghuangLinLeach, I MateoI MateoLeachFord, IanIanFordGuessous, IdrisIdrisGuessousRudan, IgorIgorRudanProkopenko, IngaIngaProkopenkoBorecki, IngridIngridBoreckiHeid, Iris MIris MHeidKolcic, IvanaIvanaKolcicPersico, IvanaIvanaPersicoJukema, J WouterJ WouterJukemaWilson, James FJames FWilsonFelix, Janine FJanine FFelixDivers, JasminJasminDiversLambert, Jean-CharlesJean-CharlesLambertStafford, Jeanette MJeanette MStaffordGaspoz, Jean-MichelJean-MichelGaspozSmith, Jennifer AJennifer ASmithFaul, Jessica DJessica DFaulWang, Jie JinJie JinWangDing, JingzhongJingzhongDingHirschhorn, Joel NJoel NHirschhornAttia, JohnJohnAttiaWhitfield, John BJohn BWhitfieldChalmers, JohnJohnChalmersViikari, JormaJormaViikariCoresh, JosefJosefCoreshDenny, Joshua CJoshua CDennyKarjalainen, JuhaJuhaKarjalainenFernandes, Jyotika KJyotika KFernandesEndlich, KarlhansKarlhansEndlichButterbach, KatjaKatjaButterbachKeene, Keith LKeith LKeeneLohman, KurtKurtLohmanPortas, LauraLauraPortasLauner, Lenore JLenore JLaunerLyytikäinen, Leo-PekkaLeo-PekkaLyytikäinenYengo, LoicLoicYengoFranke, LudeLudeFrankeFerrucci, LuigiLuigiFerrucciRose, Lynda MLynda MRoseKedenko, LyudmylaLyudmylaKedenkoRao, MadhumathiMadhumathiRaoStruchalin, MaksimMaksimStruchalinKleber, Marcus EMarcus EKleberCavalieri, MargheritaMargheritaCavalieriHaun, MargotMargotHaunCornelis, Marilyn CMarilyn CCornelisCiullo, MarinaMarinaCiulloPirastu, MarioMarioPirastude Andrade, MarizaMarizade AndradeMcEvoy, Mark AMark AMcEvoyWoodward, MarkMarkWoodwardAdam, MartinMartinAdamCocca, MassimilianoMassimilianoCoccaNauck, MatthiasMatthiasNauckImboden, MedeaMedeaImbodenWaldenberger, MelanieMelanieWaldenbergerPruijm, MennoMennoPruijmMetzger, MarieMarieMetzgerStumvoll, MichaelMichaelStumvollEvans, Michele KMichele KEvansSale, Michele MMichele MSaleKähönen, MikaMikaKähönenBoban, MladenMladenBobanBochud, MurielleMurielleBochudRheinberger, MyriamMyriamRheinbergerVerweij, NiekNiekVerweijBouatia-Naji, NabilaNabilaBouatia-NajiMartin, Nicholas GNicholas GMartinHastie, NickNickHastieProbst-Hensch, NicoleNicoleProbst-HenschSoranzo, NicoleNicoleSoranzoDevuyst, OlivierOlivierDevuystRaitakari, OlliOlliRaitakariGottesman, OmriOmriGottesmanFranco, Oscar HOscar HFrancoPolasek, OzrenOzrenPolasekGasparini, PaoloPaoloGaspariniMunroe, Patricia BPatricia BMunroeRidker, Paul MPaul MRidkerMitchell, PaulPaulMitchellMuntner, PaulPaulMuntnerMeisinger, ChristaChristaMeisingerSmit, Johannes HJohannes HSmitKovacs, PeterPeterKovacsWild, Philipp SPhilipp SWildFroguel, PhilippePhilippeFroguelRettig, RainerRainerRettigMägi, ReedikReedikMägiBiffar, ReinerReinerBiffarSchmidt, ReinholdReinholdSchmidtMiddelberg, Rita P SRita P SMiddelbergCarroll, Robert JRobert JCarrollPenninx, Brenda WBrenda WPenninxScott, Rodney JRodney JScottKatz, RonitRonitKatzSedaghat, SanazSanazSedaghatWild, Sarah HSarah HWildKardia, Sharon L RSharon L RKardiaUlivi, SheilaSheilaUliviHwang, Shih-JenShih-JenHwangEnroth, StefanStefanEnrothKloiber, StefanStefanKloiberTrompet, StellaStellaTrompetStengel, BenedicteBenedicteStengelHancock, Stephen JStephen JHancockTurner, Stephen TStephen TTurnerRosas, Sylvia ESylvia ERosasStracke, SylviaSylviaStrackeHarris, Tamara BTamara BHarrisZeller, TanjaTanjaZellerZemunik, TatijanaTatijanaZemunikLehtimäki, TerhoTerhoLehtimäkiIllig, ThomasThomasIlligAspelund, ThorThorAspelundNikopensius, TiitTiitNikopensiusEsko, TonuTonuEskoTanaka, ToshikoToshikoTanakaGyllensten, UlfUlfGyllenstenVölker, UweUweVölkerEmilsson, ValurValurEmilssonVitart, VeroniqueVeroniqueVitartAalto, VilleVilleAaltoGudnason, VilmundurVilmundurGudnasonChouraki, VincentVincentChourakiChen, Wei-MinWei-MinChenIgl, WilmarWilmarIglMärz, WinfriedWinfriedMärzKoenig, WolfgangWolfgangKoenigLieb, WolfgangWolfgangLiebLoos, Ruth J FRuth J FLoosLiu, YongmeiYongmeiLiuSnieder, HaroldHaroldSniederPramstaller, Peter PPeter PPramstallerParsa, AfshinAfshinParsaO'Connell, Jeffrey RJeffrey RO'ConnellSusztak, KatalinKatalinSusztakHamet, PavelPavelHametTremblay, JohanneJohanneTremblayde Boer, Ian HIan Hde BoerBöger, Carsten ACarsten ABögerGoessling, WolframWolframGoesslingChasman, Daniel IDaniel IChasmanKöttgen, AnnaAnnaKöttgenKao, W H LindaW H LindaKaoFox, Caroline SCaroline SFox2024-10-252024-10-252016-01-21https://boris-portal.unibe.ch/handle/20.500.12422/153358Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.en500 - Science::570 - Life sciences; biologyarticle10.7892/boris.1014342683119910.1038/ncomms10023