Evangelou, EvangelosEvangelosEvangelouGao, HeHeGaoChu, CongyingCongyingChuNtritsos, GeorgiosGeorgiosNtritsosBlakeley, PaulPaulBlakeleyButts, Andrew RAndrew RButtsPazoki, RahaRahaPazokiSuzuki, HideakiHideakiSuzukiKoskeridis, FotiosFotiosKoskeridisYiorkas, Andrianos MAndrianos MYiorkasKaraman, IbrahimIbrahimKaramanElliott, JoshuaJoshuaElliottLuo, QiangQiangLuoAeschbacher, StefanieStefanieAeschbacherBartz, Traci MTraci MBartzBaumeister, Sebastian ESebastian EBaumeisterBraund, Peter SPeter SBraundBrown, Michael RMichael RBrownBrody, Jennifer AJennifer ABrodyClarke, Toni-KimToni-KimClarkeDimou, NikiNikiDimouFaul, Jessica DJessica DFaulHomuth, GeorgGeorgHomuthJackson, Anne UAnne UJacksonKentistou, Katherine AKatherine AKentistouJoshi, Peter KPeter KJoshiLemaitre, Rozenn NRozenn NLemaitreLind, Penelope APenelope ALindLyytikäinen, Leo-PekkaLeo-PekkaLyytikäinenMangino, MassimoMassimoManginoMilaneschi, YuriYuriMilaneschiNelson, Christopher PChristopher PNelsonNolte, Ilja MIlja MNoltePerälä, Mia-MariaMia-MariaPeräläPolasek, OzrenOzrenPolasekPorteous, DavidDavidPorteousRatliff, Scott MScott MRatliffSmith, Jennifer AJennifer ASmithStančáková, AlenaAlenaStančákováTeumer, AlexanderAlexanderTeumerTuominen, SamuliSamuliTuominenThériault, SébastienSébastienThériaultVangipurapu, JagadishJagadishVangipurapuWhitfield, John BJohn BWhitfieldWood, AlexisAlexisWoodYao, JieJieYaoYu, BingBingYuZhao, WeiWeiZhaoArking, Dan EDan EArkingAuvinen, JuhaJuhaAuvinenLiu, ChunyuChunyuLiuMännikkö, MinnaMinnaMännikköRisch, LorenzLorenzRisch0000-0003-2692-6699Rotter, Jerome IJerome IRotterSnieder, HaroldHaroldSniederVeijola, JuhaJuhaVeijolaBlakemore, Alexandra IAlexandra IBlakemoreBoehnke, MichaelMichaelBoehnkeCampbell, HarryHarryCampbellConen, DavidDavidConenEriksson, Johan GJohan GErikssonGrabe, Hans JHans JGrabeGuo, XiuqingXiuqingGuovan der Harst, PimPimvan der HarstHartman, Catharina ACatharina AHartmanHayward, CarolineCarolineHaywardHeath, Andrew CAndrew CHeathJarvelin, Marjo-RiittaMarjo-RiittaJarvelinKähönen, MikaMikaKähönenKardia, Sharon L RSharon L RKardiaKühne, MichaelMichaelKühneKuusisto, JohannaJohannaKuusistoLaakso, MarkkuMarkkuLaaksoLahti, JariJariLahtiLehtimäki, TerhoTerhoLehtimäkiMcIntosh, Andrew MAndrew MMcIntoshMohlke, Karen LKaren LMohlkeMorrison, Alanna CAlanna CMorrisonMartin, Nicholas GNicholas GMartinOldehinkel, Albertine JAlbertine JOldehinkelPenninx, Brenda W J HBrenda W J HPenninxPsaty, Bruce MBruce MPsatyRaitakari, Olli TOlli TRaitakariRudan, IgorIgorRudanSamani, Nilesh JNilesh JSamaniScott, Laura JLaura JScottSpector, Tim DTim DSpectorVerweij, NiekNiekVerweijWeir, David RDavid RWeirWilson, James FJames FWilsonLevy, DanielDanielLevyTzoulaki, IoannaIoannaTzoulakiBell, Jimmy DJimmy DBellMatthews, Paul MPaul MMatthewsRothenfluh, AdrianAdrianRothenfluhDesrivières, SylvaneSylvaneDesrivièresSchumann, GunterGunterSchumannElliott, PaulPaulElliott2024-10-112024-10-112019-09https://boris-portal.unibe.ch/handle/20.500.12422/89059Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d-1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.en600 - Technology::610 - Medicine & healtharticle10.48350/1749913135897410.1038/s41562-019-0653-z