# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
600 - Technology::610 - Medicine & health

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Tutivillus and the Policing of Speech in Oxford, Bodleian Library, MS Douce 104

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Institut für Englische Sprachen und Literaturen

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.ispartofbook[].value
Middle English Lyrics: New Readings of Short Poems

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of English Languages and Literatures

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
800 - Literature, rhetoric & criticism::820 - English & Old English literatures

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
400 - Language::420 - English & Old English languages

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Tutivillus and the Policing of Speech in Oxford, Bodleian Library, MS Douce 104

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Institut für Englische Sprachen und Literaturen

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Global Social History: Class and Social Transformation in World History

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of History, Modern and Contemporary History

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
900 - History::970 - History of North America

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
900 - History::980 - History of South America

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Global Social History: Class and Social Transformation in World History

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Political Brokers and Entrepreneurs: Distinguishing Between Exceptional Agents

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
This article contributes to the theoretical discussion about the crucial position of entrepreneurs and brokers in policy networks and provides a test through the analysis of empirical data. Previous studies have demonstrated that exceptional agents play a crucial role in affecting policy outputs and influencing policy change (Schneider and Teske, 1995; Mintrom and Vergari, 1996; Christopoulos, 2006; Ingold, 2008). Earlier empirical analysis however rarely distinguishes entrepreneurs and brokers who are assumed to have similar relational profiles. Policy process theories however, regardless of whether theorized as advocacy coalitions, policy streams or punctuated equilibria invariably accord entrepreneurs and brokers different roles: brokers are assumed to facilitate negotiations and to affect stability within and across networks; while entrepreneurs are assumed to strategically attempt to influence outputs and to gain access in decision making.
Based on network theory and original empirical data, we are able to refine existing conceptual definitions and provide an operationalisation that distinguishes between entrepreneurs and brokers. In our conclusions we offer support to a comprehensive approach in capturing exceptional political action, one that combines data from actors relational profile and attributes with an analysis of a contextual setting on event parameters.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.conference[].value
Sunbelt XXX International Network for Social Network Analysis (INSNA) Conference

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Oeschger Centre for Climate Change Research (OCCR)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
300 - Social sciences, sociology & anthropology::320 - Political science

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Political Brokers and Entrepreneurs: Distinguishing Between Exceptional Agents

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Sustainable Soil Governance and Large-Scale Land Acquisitions Originating in Switzerland

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Sustainable Soil Governance and Large-Scale Land Acquisitions Originating in Switzerland

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
„Man kann auf Dauer nur an etwas glauben, das man schön gefunden hat.“ Interview mit Fulbert Steffensky

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
200 - Religion::230 - Christianity & Christian theology

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
200 - Religion::240 - Christian practice & observance

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
„Man kann auf Dauer nur an etwas glauben, das man schön gefunden hat.“ Interview mit Fulbert Steffensky

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Integrated medical treatment in children suffering from attention deficit disorder with and without hyperactivity - long-term follow-up

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.conference[].value
4th European Congress for Integrated Medicine

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of Complementary and Integrative Medicine (IKIM)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Integrated medical treatment in children suffering from attention deficit disorder with and without hyperactivity - long-term follow-up

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Dank Bibliosuisse konnten sechs Newcomer nach Athen an den World Library and Information Congress (WLIC) reisen. Ein Erfahrungsbericht.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
000 - Computer science, knowledge & systems::020 - Library & information sciences

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Glycoprotein D of bovine herpesvirus 5 (BoHV-5) confers an extended host range to BoHV-1 but does not contribute to invasion of the brain

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Bovine herpesvirus 1 (BoHV-1) and BoHV-5 are closely related pathogens of cattle, but only BoHV-5 is considered a neuropathogen. We engineered intertypic gD exchange mutants with BoHV-1 and BoHV-5 backbones in order to address their in vitro and in vivo host ranges, with particular interest in invasion of the brain. The new viruses replicated in cell culture with similar dynamics and to titers comparable to those of their wild-type parents. However, gD of BoHV-5 (gD5) was able to interact with a surprisingly broad range of nectins. In vivo, gD5 provided a virulent phenotype to BoHV-1 in AR129 mice, featuring a high incidence of neurological symptoms and early onset of disease. However, only virus with the BoHV-5 backbone, independent of the gD type, was detected in the brain by immunohistology. Thus, gD of BoHV-5 confers an extended cellular host range to BoHV-1 and may be considered a virulence factor but does not contribute to the invasion of the brain.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Institut für Veterinär-Bakteriologie der Universität Bern

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of Veterinary Bacteriology (IVB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Glycoprotein D of bovine herpesvirus 5 (BoHV-5) confers an extended host range to BoHV-1 but does not contribute to invasion of the brain

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Institut für Veterinär-Bakteriologie der Universität Bern

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
productivity, non-tariff barriers, and openness

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
PRONTO is a collaborative research project on regulatory barriers to trade, supported by the European Commission under the FP7 programme.

Over the past fifty years, there has been significant progress in lowering tariff barriers to international trade. This has led to a growing awareness of the importance of what are termed the "new” Non-Tariff Measures (NTMs). The relevance of these new NTMs has grown with the rising importance of global sourcing and multinational enterprises. Today, with the dominance of global value chains and the increased tradability of non-tangible products, we are confronted with new and important questions about the impact of NTMs on competitiveness and productivity. The team working on PRONTO seeks new and better data, better methodologies, and better understanding of the impact of new NTMs on international investment and trade. This involves a collaborative effort between universities and those international organizations working on primary data development, with an important long-term goal being sustainability of information resources for tracking and guiding international economic policy in this area.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
productivity, non-tariff barriers, and openness

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Discussing Heller’s The Nuremberg Military Tribunals and the Origins of the International Criminal Law

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.note[].value
Blog of the European Journal of International Law

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Historisches Institut, Neueste Geschichte und Zeitgeschichte

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of History, Modern and Contemporary History

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Discussing Heller’s The Nuremberg Military Tribunals and the Origins of the International Criminal Law

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Historisches Institut, Neueste Geschichte und Zeitgeschichte

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Projektbericht SAPERE (Scripta Antiquitatis Posterioris ad Ethicam Religionemque pertinentia/Schriften der Späten Antike zu ethischen und religiösen Fragen)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Institut für Bibelwissenschaft, Neues Testament

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of Biblical Studies, New Testament

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Projektbericht SAPERE (Scripta Antiquitatis Posterioris ad Ethicam Religionemque pertinentia/Schriften der Späten Antike zu ethischen und religiösen Fragen)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Institut für Bibelwissenschaft, Neues Testament

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Estimating the Number of Debris in the Geostationary Ring

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Astronomisches Institut der Universität Bern (AIUB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Estimating the Number of Debris in the Geostationary Ring

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Astronomisches Institut der Universität Bern (AIUB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Astronomisches Institut der Universität Bern (AIUB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Are the European reference networks for rare diseases ready to embrace machine learning? A mixed-methods study.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
BACKGROUND

The delay in diagnosis for rare disease (RD) patients is often longer than for patients with common diseases. Machine learning (ML) technologies have the potential to speed up and increase the precision of diagnosis in this population group. We aim to explore the expectations and experiences of the members of the European Reference Networks (ERNs) for RDs with those technologies and their potential for application.

METHODS

We used a mixed-methods approach with an online survey followed by a focus group discussion. Our study targeted primarily medical professionals but also other individuals affiliated with any of the 24 ERNs.

RESULTS

The online survey yielded 423 responses from ERN members. Participants reported a limited degree of knowledge of and experience with ML technologies. They considered improved diagnostic accuracy the most important potential benefit, closely followed by the synthesis of clinical information, and indicated the lack of training in these new technologies, which hinders adoption and implementation in routine care. Most respondents supported the option that ML should be an optional but recommended part of the diagnostic process for RDs. Most ERN members saw the use of ML limited to specialised units only in the next 5 years, where those technologies should be funded by public sources. Focus group discussions concluded that the potential of ML technologies is substantial and confirmed that the technologies will have an important impact on healthcare and RDs in particular. As ML technologies are not the core competency of health care professionals, participants deemed a close collaboration with developers necessary to ensure that results are valid and reliable. However, based on our results, we call for more research to understand other stakeholders' opinions and expectations, including the views of patient organisations.

CONCLUSIONS

We found enthusiasm to implement and apply ML technologies, especially diagnostic tools in the field of RDs, despite the perceived lack of experience. Early dialogue and collaboration between health care professionals, developers, industry, policymakers, and patient associations seem to be crucial to building trust, improving performance, and ultimately increasing the willingness to accept diagnostics based on ML technologies.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject[].value
Artificial intelligence Diagnosis Diagnostic delay European reference networks Machine learning Rare diseases

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
300 - Social sciences, sociology & anthropology::350 - Public administration & military science

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Are the European reference networks for rare diseases ready to embrace machine learning? A mixed-methods study.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation3[].value
sitem Zentrum für Translationale Medizin und Biomedizinisches Unternehmertum

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Stratification of high-risk prostate cancer into prognostic categories: a European multi-institutional study

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
BACKGROUND

High-risk prostate cancer (PCa) is an extremely heterogeneous disease. A clear definition of prognostic subgroups is mandatory.

OBJECTIVE

To develop a pretreatment prognostic model for PCa-specific survival (PCSS) in high-risk PCa based on combinations of unfavorable risk factors.

DESIGN, SETTING, AND PARTICIPANTS

We conducted a retrospective multicenter cohort study including 1360 consecutive patients with high-risk PCa treated at eight European high-volume centers.

INTERVENTION

Retropubic radical prostatectomy with pelvic lymphadenectomy.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS

Two Cox multivariable regression models were constructed to predict PCSS as a function of dichotomization of clinical stage (< cT3 vs cT3-4), Gleason score (GS) (2-7 vs 8-10), and prostate-specific antigen (PSA; ≤ 20 ng/ml vs > 20 ng/ml). The first "extended" model includes all seven possible combinations; the second "simplified" model includes three subgroups: a good prognosis subgroup (one single high-risk factor); an intermediate prognosis subgroup (PSA >20 ng/ml and stage cT3-4); and a poor prognosis subgroup (GS 8-10 in combination with at least one other high-risk factor). The predictive accuracy of the models was summarized and compared. Survival estimates and clinical and pathologic outcomes were compared between the three subgroups.

RESULTS AND LIMITATIONS

The simplified model yielded an R(2) of 33% with a 5-yr area under the curve (AUC) of 0.70 with no significant loss of predictive accuracy compared with the extended model (R(2): 34%; AUC: 0.71). The 5- and 10-yr PCSS rates were 98.7% and 95.4%, 96.5% and 88.3%, 88.8% and 79.7%, for the good, intermediate, and poor prognosis subgroups, respectively (p = 0.0003). Overall survival, clinical progression-free survival, and histopathologic outcomes significantly worsened in a stepwise fashion from the good to the poor prognosis subgroups. Limitations of the study are the retrospective design and the long study period.

CONCLUSIONS

This study presents an intuitive and easy-to-use stratification of high-risk PCa into three prognostic subgroups. The model is useful for counseling and decision making in the pretreatment setting.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
600 - Technology::610 - Medicine & health

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Stratification of high-risk prostate cancer into prognostic categories: a European multi-institutional study

# _embedded.facets[]._embedded.values[].label
300 - Social sciences, sociology & anthropology