# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Gebautes und Gottgeschaffenes. Vorstellungen vom Orient und einem biblischen Hebräertum in der jüdischen Architektur in Palästina

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Modernity and early cultures. Reconsidering non-western references for modern architecture in cross-cultural perspective

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Gebautes und Gottgeschaffenes. Vorstellungen vom Orient und einem biblischen Hebräertum in der jüdischen Architektur in Palästina

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Institut für theoretische Physik der Universität Bern (ITP)

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Institut für theoretische Physik der Universität Bern (ITP)

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A papain-induced disc degeneration model for the assessment of thermo-reversible hydrogel-cells therapeutic approach

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Nucleus pulposus (NP) regeneration by the application of injectable cell-embedded hydrogels is an appealing approach for tissue engineering. We investigated a thermo-reversible hydrogel (TR-HG), based on a modified polysaccharide with a thermo-reversible polyamide [poly(N-isopropylacrylamide), pNIPAM], which is made to behave as a liquid at room temperature and hardens at > 32 °C. In order to test the hydrogel, a papain-induced bovine caudal disc degeneration model (PDDM), creating a cavity in the NP, was employed. Human mesenchymal stem cells (hMSCs) or autologous bovine NP cells (bNPCs) were seeded in TR-HG; hMSCs were additionally preconditioned with rhGDF-5 for 7 days. Then, TR-HG was reversed to a fluid and the cell suspension injected into the PDDM and kept under static loading for 7 days. Experimental design was: (D1) fresh disc control + PBS injection; (D2) PDDM + PBS injection; (D3) PDDM + TR-HG (material control); (D4) PDDM + TR-HG + bNPCs; (D5) PDDM + TR-HG + hMSCs. Magnetic resonance imaging performed before and after loading, on days 9 and 16, allowed imaging of the hydrogel-filled PDDM and assessment of disc height and volume changes. In gel-injected discs the NP region showed a major drop in volume and disc height during culture under static load. The RT–PCR results of injected hMSCs showed significant upregulation of ACAN, COL2A1, VCAN and SOX9 during culture in the disc cavity, whereas the gene expression profile of NP cells remained unchanged. The cell viability of injected cells (NPCs or hMSCs) was maintained at over 86% in 3D culture and dropped to ~72% after organ culture. Our results underline the need for load-bearing hydrogels that are also cyto-compatible.

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Institut für chirurgische Technologien und Biomechanik (ISTB)

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Institut für Diagnostische, Interventionelle und Pädiatrische Radiologie

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.ispartof[].value
Journal of tissue engineering and regenerative medicine

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Institute for Surgical Technology and Biomechanics (ISTB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of Diagnostic, Interventional and Paediatric Radiology

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500 - Science::570 - Life sciences; biology

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600 - Technology::610 - Medicine & health

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
A papain-induced disc degeneration model for the assessment of thermo-reversible hydrogel-cells therapeutic approach

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Institut für chirurgische Technologien und Biomechanik (ISTB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Institut für Diagnostische, Interventionelle und Pädiatrische Radiologie

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Institut für chirurgische Technologien und Biomechanik (ISTB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
This is a concise encyclopedia entry that discusses the applicable law of the World Trade Organization (WTO) with regard to telecommunications, audiovisual, postal and courier services, which are framed in terms of existing WTO classification under the common heading of 'Communication Services'. The chapter analyzes the pertinent rules of the General Agreement on Trade in Services (GATS), the present state of commitments, the problems faced in light of the recent technological advances that affect, albeit differently, all these sectors. It includes insights from the case-law and a brief overall appraisal of the prospects for change.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.ispartofbook[].value
Encyclopedia of International Economic Law

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
300 - Social sciences, sociology & anthropology::340 - Law

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
300 - Social sciences, sociology & anthropology::380 - Commerce, communications & transportation

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Geschichte eines Landes ohne Landesgeschichte. Aspekte der Geschichte der alten Eidgenossenschaft in forschungskritischer Perspektive. Kolloquium Hirschberg (Bayern), 4.-5. März 2010

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Geschichte eines Landes ohne Landesgeschichte. Aspekte der Geschichte der alten Eidgenossenschaft in forschungskritischer Perspektive. Kolloquium Hirschberg (Bayern), 4.-5. März 2010

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
When a child is not following the normal, predicted growth curve, an evaluation for underlying illness and central nervous system abnormalities is required and appropriate consideration should be given to genetic defects causing growth hormone (GH) deficiency. This article focuses on the GH gene, the various gene alterations, and their possible impact on the pituitary gland. Transcription factors regulating pituitary gland development may cause multiple pituitary hormone deficiency but may present initially as GH deficiency. The role of two most important transcription factors, POU1F1 (Pit-1) and PROP 1, is discussed.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.ispartof[].value
Endocrinology and metabolism clinics of North America

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Synchronous Holocene climatic oscillations recorded on the Swiss Plateau and at timberline in the Alps

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Eight synchronous pre-Roman cold phases were found at 9600–9200, 8600–8150, 7550–6900, 6600– 6200, 5350–4900, 4600–4400, 3500–3200 and 2600–2350 radiocarbon years BP by reconstructing past climate at two sites on the Swiss Plateau and at timberline in the Alps. The cooling events during the early-and mid-Holocene represent temperature values similar to today, and apparently the onset of cooling events represents a deviation from today's mean annual temperature of about 1°C and is triggered at a 1000-year periodicity. At Wallisellen-Langachermoos (440 m), a former oligotrophic lake near Zürich, the correlation between sum mertime lake levels and the seed production of the amphi-Atlantic aquatic plantNajas flexilis was used to reconstruct lake levels over a 3000-year period during the first part of the Holocene. At Lake Seedorf on the western Swiss Plateau (609 m) the sedimentological, palynological and macrofossil record revealed fluctuations of lake levels for the complete Holocene. From Lago Basso in the southern Alps (2250 m, Val San Giacomo near Splügen Pass, Northern Italy) the terrestrial plant macrofossils – especiallyPinus cembra andLarix – allowed the reconstruction of timberline fluctuations controlled by climate. A similar climatic pattern was found at Gouillé Rion pond in the central Swiss Alps (2343 m, Val d'Hérémence) with plant macrofossils and pollen concentrations and percentages. We postulate that these climatic events are detectable throughout central Europe by independent methods in combination with precise AMS-radiocarbon datings on terrestrial plant remains. Our data fit other proxy records of regional climatic change, such as cool intervals from Greenland ice cores, glacier movements in the Swiss and Austrian Alps, and dendro-densitometry on subfossil wood, as well as the palaeoclimatic data from the Jura Mountains of France obtained by sedimentological analyses. Thus our data indicate that the Northern Hemisphere climate was less stable during the Holocene than previously believed.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Oeschger Centre for Climate Change Research, NCCR Climate

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Institute of Plant Sciences, Palaeoecology

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of Plant Sciences, Palaeoecology

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Synchronous Holocene climatic oscillations recorded on the Swiss Plateau and at timberline in the Alps

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.unibe.additional.sponsorship[].value
Oeschger Centre for Climate Change Research, NCCR Climate

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.unibe.additional.sponsorship[].value
Institute of Plant Sciences, Palaeoecology

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Reducing road traffic noise: How to design effective individual-based interventions

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.conference[].value
5th International Conference on Traffic and Transport Psychology

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Interdisciplinary Centre for General Ecology (IKAÖ)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
300 - Social sciences, sociology & anthropology

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
300 - Social sciences, sociology & anthropology::380 - Commerce, communications & transportation

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
600 - Technology::610 - Medicine & health

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Reducing road traffic noise: How to design effective individual-based interventions

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Ethyl sulphate and ethyl glucuronide in vitreous humor as postmortem evidence marker for ethanol consumption prior to death

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To clarify the circumstances of death, the degree of inebriation is of importance in many cases, but for several reasons the determination of the ethanol concentration in post-mortem samples can be challenging and the synopsis of ethanol and the direct consumption markers ethyl glucuronide (EtG) and ethyl sulphate (EtS) has proved to be useful. The use of a rather stable matrix like vitreous humor offers further advantages. The aim of this study was to determine the concentrations of ethanol and the biomarkers in the robust matrix of vitreous humor and to compare them with the respective levels in peripheral venous blood and urine. Samples of urine, blood from the femoral vein and vitreous humor were taken from 26 deceased with suspected ethanol consumption prior to death and analyzed for ethanol, EtS and EtG. In the urine samples creatinine was also determined. The personal data, the circumstances of death, the post-mortem interval and the information about ethanol consumption prior to death were recorded. EtG and EtS analysis in urine was performed by LC-ESI-MS/MS, creatinine concentration was determined using the Jaffé reaction and ethanol was detected by HS-GC-FID and by an ADH-based method. In general, the highest concentrations of the analytes were found in urine and showed statistical significance. The mean concentrations of EtG were 62.8mg/L (EtG100 206.5mg/L) in urine, 4.3mg/L in blood and 2.1mg/L in vitreous humor. EtS was found in the following mean concentrations: 54.6mg/L in urine (EtS100 123.1mg/L), 1.8mg/L in blood and 0.9mg/L in vitreous humor. Ethanol was detected in more vitreous humor samples (mean concentration 2.0g/kg) than in blood and urine (mean concentration 1.6g/kg and 2.1g/kg respectively). There was no correlation between the ethanol and the marker concentrations and no statistical conclusions could be drawn between the markers and matrices.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Ethyl sulphate and ethyl glucuronide in vitreous humor as postmortem evidence marker for ethanol consumption prior to death

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Mars Soil Temperature and Thermal Properties From InSight HP3 Data

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Diurnal and seasonal variations in soil and surface temperature measured with the  thermal probe and radiometer of NASA's InSight Mars mission are reported. At a representative depth of 10–20 cm, an average temperature of 217.5 K was found, varying by 5.3–6.7 K during a sol and by 13.3 K during the seasons. From the damping of the temperature variation with depth and the phase shift, a thermal diffusivity of (3.93  0.39) ×  /s was derived for the upper 10 cm from the diurnal temperature variation and of (3.63  0.53) ×  /s for the 40 cm depth range of the mole from the annual temperature variation. Using published thermal conductivity and inertia values together with the diffusivities, soil densities of 1,470 and 1,730 kg/ were derived for these depths. The temperatures allow the deliquescence of thin films of brine, the efflorescence of which may explain the cemented duricrust observed.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Mars Soil Temperature and Thermal Properties From InSight HP3 Data

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.organization[].value
Institute of Systematic Theology, Ethics

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.editor.affiliation[].value
Institut für Systematische Theologie, Ethik

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
The Next Wave: Are We Prepared for Patients on Anticoagulation With Factor XI Inhibitors in Cardiac Surgery?

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Clinic and Policlinic for Anaesthesiology and Pain Therapy

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.ispartof[].value
Journal of Cardiothoracic and Vascular Anesthesia

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
600 - Technology::610 - Medicine & health

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
The Next Wave: Are We Prepared for Patients on Anticoagulation With Factor XI Inhibitors in Cardiac Surgery?

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Clinic and Policlinic for Anaesthesiology and Pain Therapy

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
I am not a beggar; I am an Istanbullu: Seeking the right for a neighborhood to being dragged into Streets

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Geographisches Institut der Universität Bern (GIUB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.publisher[].value
Beyond Istanbul, Center for Spacial Justice

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.ispartofbook[].value
Special issue: children and spatial justice

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
I am not a beggar; I am an Istanbullu: Seeking the right for a neighborhood to being dragged into Streets

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Geographisches Institut der Universität Bern (GIUB)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Increased Prevalence of an Oxytocin Receptor Gene Variant in Functional Neurological Disorder: A Case-Control Study.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Objective
Current models of functional neurological disorder (FND) suggest a multifactorial origin of the disorder. Recent studies have identified biological vulnerability factors for FND, such as reduced amygdalar and hippocampal volumes or altered stress responses, highlighting the need to investigate the potential roles of genetic factors in this disorder.Methods
Eighty-five patients with mixed FND symptoms and 76 healthy control (HC) individuals were genotyped for 10 single-nucleotide polymorphisms (SNPs) in seven genes associated with the brain's stress response system. For genetic variants that were found to be linked to FND, associations with structural brain alterations were investigated by using a region-of-interest approach in a subset of FND patients with complete genotyping and neuroimaging data (N=82). Regions had been previously selected on the basis of their biological involvement and being a factor in vulnerability to FND.Results
A significant association between FND and a SNP, rs53576, in the oxytocin receptor (OXTR) gene was observed, and a significant association between decreased right insular volumes and rs53576 was also identified. Among female FND patients (N=60), the rs53576 SNP in OXTR was associated with significantly reduced bilateral amygdalar volume.Conclusions
These preliminary results suggest that genetic factors in the oxytocinergic system and sex-specific structural changes in the insula and amygdala contribute to vulnerability to FND. Because oxytocin is a regulatory factor in stress responses, decreased activity of some FND-associated OXTR gene variants might affect stress responses and regulation in FND in a sex-dependent manner.

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S. Webers Rolle 2022 ausgelaufen, eb/22.9.2025

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Graduate School for Health Sciences (GHS)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Clinic of Neurology, Centre of Competence for Psychosomatic Medicine

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.ispartof[].value
The Journal of Neuropsychiatry and Clinical Neurosciences

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
600 - Technology::610 - Medicine & health

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Increased Prevalence of an Oxytocin Receptor Gene Variant in Functional Neurological Disorder: A Case-Control Study.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Graduate School for Health Sciences (GHS)

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Clinic of Neurology, Centre of Competence for Psychosomatic Medicine

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Managing Organizational Responsiveness : Toward a Theory of Responsive Practice

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
300 - Social sciences, sociology & anthropology::350 - Public administration & military science

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Managing Organizational Responsiveness : Toward a Theory of Responsive Practice

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
BACKGROUND

IL-6 (interleukin-6) has important roles in atherosclerosis pathophysiology. To determine if anti-IL-6 therapy warrants evaluation as an adjuvant stroke prevention strategy in patients with carotid atherosclerosis, we tested whether circulating IL-6 levels predict carotid plaque severity, vulnerability, and progression in the prospective population-based CHS (Cardiovascular Health Study).

METHODS

Duplex carotid ultrasound was performed at baseline and 5 years. Baseline plaque severity was scored 0 to 5 based on North American Symptomatic Carotid Endarterectomy Trial grade of stenosis. Plaque vulnerability at baseline was the presence of markedly irregular, ulcerated, or echolucent plaques. Plaque progression at 5 years was a ≥1 point increase in stenosis severity. The relationship of baseline plasma IL-6 levels with plaque characteristics was modeled using multivariable linear (severity) or logistic (vulnerability and progression) regression. Risk factors of atherosclerosis were included as independent variables. Stepwise backward elimination was used with P>0.05 for variable removal. To assess model stability, we computed the E-value or minimum strength of association (odds ratio scale) that unmeasured confounders must have with log IL-6 and the outcome to suppress the association. We performed internal validation with 100 bootstrap samples.

RESULTS

There were 4334 participants with complete data (58.9% women, mean age: 72.7±5.1 years), including 1267 (29.2%) with vulnerable plaque and 1474 (34.0%) with plaque progression. Log IL-6 predicted plaque severity (β=0.09, P=1.3×10-3), vulnerability (OR, 1.21 [95% CI, 1.05-1.40]; P=7.4×10-3, E-value=1.71), and progression (OR, 1.44 [95% CI, 1.23-1.69], P=9.1×10-6, E-value 2.24). In participants with >50% predicted probability of progression, mean log IL-6 was 0.54 corresponding to 2.0 pg/mL. Dichotomizing IL-6 levels did not affect the performance of prediction models.

CONCLUSIONS

Circulating IL-6 predicts carotid plaque severity, vulnerability, and progression. The 2.0 pg/mL cutoff could facilitate the selection of individuals that would benefit from anti-IL-6 drugs for stroke prevention.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
600 - Technology::610 - Medicine & health

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Equilibrium radionuclide angiography: Intra- and inter-observer repeatability and reproducibility in the assessment of cardiac systolic and diastolic function.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
BACKGROUND

This study aimed to assess intra- and inter-observer agreement in assessing the systolic and diastolic function with equilibrium radionuclide angiography (ERNA).

MATERIALS AND METHODS

Thirty-two adults underwent baseline and repeat ERNA. An experienced and a trainee operator analyzed the data by assigning regions of interest manually, fully automatically, and semi-automatically. The Bland-Altman statistic (mean ± 1.96 standard deviations of the differences) was used to assess the repeatability (two different assessments of a single acquisition) and reproducibility (assessments of two different acquisitions).

RESULTS

Using the semi-automated technique the intraobserver repeatability and reproducibility of left ventricular ejection fraction for the experienced physician were - 0.1 ± 3.7 and 0.0 ± 3.8 and for the trainee 2.2 ± 10.6 and 1.9 ± 8.4, respectively. The inter-observer repeatability and reproducibility were - 1.8 ± 6.4 and 0.4 ± 9.0, respectively. Among the parameters of diastolic function, the intraobserver repeatability and reproducibility of the peak filling rate for the experienced physician were - 0.0 ± 1.1 and - 0.1 ± 1.1 and for the trainee 0.2 ± 3.5 and 0.4 ± 3.7, respectively. The inter-observer repeatability and reproducibility were 0.3 ± 1.5 and 0.5 ± 4.0, respectively. Similar was the pattern for the other diastolic indices. In all cases the limits of agreement varied according to the quantification approach.

CONCLUSION

A good repeatability but a moderate reproducibility was found in the assessment of the LVEF. Less good were the findings in the assessment of diastolic function.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.subject.ddc[].value
600 - Technology::610 - Medicine & health

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Equilibrium radionuclide angiography: Intra- and inter-observer repeatability and reproducibility in the assessment of cardiac systolic and diastolic function.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
BACKGROUND: Hydrochlorothiazide (HCT) is applied in the therapy of familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC) caused by claudin-16 (CLDN16) mutation. However, the short-term efficacy of HCT to reduce hypercalciuria in FHHNC has not yet been demonstrated in a clinical trial. METHODS: Four male and four female patients with FHHNC and CLDN16 mutation, under long-standing HCT therapy (0.4-1.2 mg/kg, median 0.9 mg/kg, dose according to calciuria), aged 0.7-22.4 years, were included in a clinical study to investigate the effect of HCT on calciuria. The study design consisted of three periods: continued therapy for 4 weeks, HCT withdrawal for 6 weeks and restart of therapy at the same dose for 4 weeks. Calciuria and magnesiuria were assessed weekly as Ca/creat and Mg/creat ratio, every 2 weeks in 24 h urine, and serum Mg, K and kaliuria (s-Mg, s-K and K/creat) at weeks 0, 6, 10 and 14. The data of each study period were averaged and analysed by Friedman and Wilcoxon test. RESULTS: Ca/creat was significantly reduced by HCT (median before/at/after withdrawal 0.76/1.24/0.77 mol/mol creat; n = 8, P<0.05). The reduction of Ca/24 h by HCT was not statistically significant (0.13/0.19/0.13 mmol/kg x 24 h; n = 5). Serum Mg (0.51/0.64/0.56 mmol/l; n = 8, P<0.05) and Serum K (3.65/4.35/3.65 mmol/l; n = 8, P<0.05) were significantly higher during withdrawal. However, Mg/creat (0.98/0.90/0.90 mol/mol creat; n = 8), Mg/24 h (0.14/0.12/0.18 mmol/kg x 24h; n = 5) and K/creat (6.3/8.4/6.2 mol/mol creat; n = 8) remained statistically unchanged during withdrawal. CONCLUSIONS: We demonstrated that HCT is effective in reducing hypercalciuria due to CLDN16 mutation on a short-term basis. However, the efficacy of HCT to attenuate disease progression remains to be elucidated.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Gender Studies in Theology and Religion: a success-story? - Conclusion, Zusammenfassender Schlussvortrag, Expert Meeting, Universität Groningen (Niederlande) 27.-28.1.2011

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Gender Studies in Theology and Religion: a success-story? - Conclusion, Zusammenfassender Schlussvortrag, Expert Meeting, Universität Groningen (Niederlande) 27.-28.1.2011

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Mass determinations of the three mini-Neptunes transiting TOI-125

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
The Transiting Exoplanet Survey Satellite, TESS, is currently carrying out an all-sky search for small planets transiting bright stars. In the first year of the TESS survey, a steady progress was made in achieving the mission’s primary science goal of establishing bulk densities for 50 planets smaller than Neptune. During that year, the TESS’s observations were focused on the southern ecliptic hemisphere, resulting in the discovery of three mini-Neptunes orbiting the star TOI-125, a V = 11.0 K0 dwarf. We present intensive HARPS radial velocity observations, yielding precise mass measurements for TOI-125b, TOI-125c, and TOI-125d. TOI-125b has an orbital period of 4.65 d, a radius of 2.726 ± 0.075 RE, a mass of 9.50 ± 0.88 ME, and is near the 2:1 mean motion resonance with TOI-125c at 9.15 d. TOI-125c has a similar radius of 2.759 ± 0.10 RE and a mass of 6.63 ± 0.99 ME, being the puffiest of the three planets. TOI-125d has an orbital period of 19.98 d and a radius of 2.93 ± 0.17 RE and mass 13.6 ± 1.2 ME. For TOI-125b and d, we find unusual high eccentricities of 0.19 ± 0.04 and $0.17^{+0.08}_{-0.06}$, respectively. Our analysis also provides upper mass limits for the two low-SNR planet candidates in the system; for TOI-125.04 (RP = 1.36 RE, P = 0.53 d), we find a 2σ upper mass limit of 1.6 ME, whereas TOI-125.05 ($R_P=4.2^{+2.4}_{-1.4}$ RE, P = 13.28 d) is unlikely a viable planet candidate with an upper mass limit of 2.7 ME. We discuss the internal structure of the three confirmed planets, as well as dynamical stability and system architecture for this intriguing exoplanet system.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Physics Institute, Space Research and Planetary Sciences

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
Center for Space and Habitability (CSH) - CHEOPS

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.relation.ispartof[].value
Monthly Notices of the Royal Astronomical Society

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Mass determinations of the three mini-Neptunes transiting TOI-125

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.oairecerif.author.affiliation[].value
Center for Space and Habitability (CSH) - CHEOPS

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.unibe.additional.sponsorship[].value
Physics Institute, Space Research and Planetary Sciences

# _embedded.facets[]._embedded.values[].label
300 - Social sciences, sociology & anthropology