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  3. Peptide receptor expression in GEP-NET
 

Peptide receptor expression in GEP-NET

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BORIS DOI
10.7892/boris.22742
Date of Publication
2007
Publication Type
Article
Division/Institute

Institut für Patholog...

Contributor
Reubi-Kattenbusch, Jean-Claude
Institut für Pathologie
Subject(s)

500 - Science::570 - ...

600 - Technology::610...

Series
Virchows Archiv
ISSN or ISBN (if monograph)
0945-6317
Publisher
Springer-Verlag
Language
English
Publisher DOI
10.1007/s00428-007-0443-2
PubMed ID
17684767
Description
Numerous peptide receptors have recently been reported to be expressed or overexpressed in various human cancers. For instance, somatostatin receptors are particularly frequently expressed in gastroenteropancreatic neuroendocrine tumors (GEP-NET), including both primaries and metastases. The density is often high, and the distribution is usually homogenous. While various somatostatin receptor subtypes can be expressed in these tumors, the sst(2) is clearly predominant. These receptors represent the molecular basis for a number of clinical applications, including symptomatic therapy with octreotide in hormone-secreting GEP-NET, in vivo diagnostic with radiolabeled diethylene triamine pentaacetic acid octreotide (Octreoscan) to evaluate the extend of the disease, and (90)Y- or (177)Lu-[(90)Y-DOTA]-D: -Phe(1)-Tyr(3) octreotide radiotherapy. GEP-NET can, however, express peptide receptors other than somatostatin receptor: Insulinomas have more glucagon-like peptide 1 receptors than somatostatin receptors; gastrinomas express very high levels of secretin receptors. GEP-NET may also express cholecystokinin 2, bombesin, neuropeptide Y, or vasoactive intestinal peptide receptors. Often, several of these peptide receptors are expressed simultaneously in GEP-NET, providing a molecular basis for in vivo multireceptor targeting of those tumors.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/96408
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