Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study
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BORIS DOI
Date of Publication
2006
Publication Type
Article
Division/Institute
Contributor
Nolan, D | |
Martin, A | |
McKinnon, E | |
Almeida, C | |
Mallal, Simon |
Series
Clinical infectious diseases
ISSN or ISBN (if monograph)
1058-4838
Publisher
The University of Chicago Press
Language
English
Publisher DOI
PubMed ID
16758424
Description
Abacavir therapy is associated with significant drug hypersensitivity in approximately 8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allele. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipients.
File(s)
File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
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43-1-99.pdf | text | Adobe PDF | 98.57 KB | published |