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  3. Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study
 

Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study

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BORIS DOI
10.7892/boris.19240
Date of Publication
2006
Publication Type
Article
Division/Institute

Universitätsklinik fü...

Contributor
Rauch, Andriorcid-logo
Universitätsklinik für Infektiologie
Nolan, D
Martin, A
McKinnon, E
Almeida, C
Mallal, Simon
Series
Clinical infectious diseases
ISSN or ISBN (if monograph)
1058-4838
Publisher
The University of Chicago Press
Language
English
Publisher DOI
10.1086/504874
PubMed ID
16758424
Description
Abacavir therapy is associated with significant drug hypersensitivity in approximately 8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allele. In this prospective study, involving 260 abacavir-naive individuals (7.7% of whom were positive for HLA-B*5701), we confirm the usefulness of genetic risk stratification, with no cases of abacavir hypersensitivity among 148 HLA-B*5701-negative recipients.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/93006
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43-1-99.pdftextAdobe PDF98.57 KBpublishedOpen
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