New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.

BORIS DOI
Publisher DOI
PubMed ID
31358974
Description
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d-1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
Date of Publication
2019-09
Publication Type
Article
Subject(s)
600 - Technology::610 - Medicine & health
Language(s)
en
Contributor(s)
Evangelou, Evangelos
Gao, He
Chu, Congying
Ntritsos, Georgios
Blakeley, Paul
Butts, Andrew R
Pazoki, Raha
Suzuki, Hideaki
Koskeridis, Fotios
Yiorkas, Andrianos M
Karaman, Ibrahim
Elliott, Joshua
Luo, Qiang
Aeschbacher, Stefanie
Bartz, Traci M
Baumeister, Sebastian E
Braund, Peter S
Brown, Michael R
Brody, Jennifer A
Clarke, Toni-Kim
Dimou, Niki
Faul, Jessica D
Homuth, Georg
Jackson, Anne U
Kentistou, Katherine A
Joshi, Peter K
Lemaitre, Rozenn N
Lind, Penelope A
Lyytikäinen, Leo-Pekka
Mangino, Massimo
Milaneschi, Yuri
Nelson, Christopher P
Nolte, Ilja M
Perälä, Mia-Maria
Polasek, Ozren
Porteous, David
Ratliff, Scott M
Smith, Jennifer A
Stančáková, Alena
Teumer, Alexander
Tuominen, Samuli
Thériault, Sébastien
Vangipurapu, Jagadish
Whitfield, John B
Wood, Alexis
Yao, Jie
Yu, Bing
Zhao, Wei
Arking, Dan E
Auvinen, Juha
Liu, Chunyu
Männikkö, Minna
Rotter, Jerome I
Snieder, Harold
Veijola, Juha
Blakemore, Alexandra I
Boehnke, Michael
Campbell, Harry
Conen, David
Eriksson, Johan G
Grabe, Hans J
Guo, Xiuqing
van der Harst, Pim
Hartman, Catharina A
Hayward, Caroline
Heath, Andrew C
Jarvelin, Marjo-Riitta
Kähönen, Mika
Kardia, Sharon L R
Kühne, Michael
Kuusisto, Johanna
Laakso, Markku
Lahti, Jari
Lehtimäki, Terho
McIntosh, Andrew M
Mohlke, Karen L
Morrison, Alanna C
Martin, Nicholas G
Oldehinkel, Albertine J
Penninx, Brenda W J H
Psaty, Bruce M
Raitakari, Olli T
Rudan, Igor
Samani, Nilesh J
Scott, Laura J
Spector, Tim D
Verweij, Niek
Weir, David R
Wilson, James F
Levy, Daniel
Tzoulaki, Ioanna
Bell, Jimmy D
Matthews, Paul M
Rothenfluh, Adrian
Desrivières, Sylvane
Schumann, Gunter
Elliott, Paul
Additional Credits
Universitätsinstitut für Klinische Chemie (UKC)
Series
Nature human behaviour
Publisher
Springer Nature
ISSN
2397-3374
Access(Rights)
open.access
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