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Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance.

BORIS DOI
Publisher DOI
PubMed ID
35852364
Description
Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We confirm the causative role of a single ispA mutation in SCV emergence and increased aminoglycoside resistance. IspA is involved in the synthesis of ubiquinone, providing a possible link between electron transport and SCV formation in P. aeruginosa.
Date of Publication
2022-07-19
Publication Type
Article
Subject(s)
Keyword(s)
Pseudomonas aeruginosa SCV aminoglycosides antibiotic resistance burn wound infection gentamicin small-colony variant tobramycin
Language(s)
en
Contributor(s)
Pagani, Jean-Luc
Fournier, Anne
Additional Credits
Series
Antimicrobial agents and chemotherapy
Publisher
American Society for Microbiology
ISSN
0066-4804
Access(Rights)
open.access
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