Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice

Date of Publication
2012
Publication Type
Article
Division/Institute

Institut für Anatomie...

Author
Dill, Michael T
Rothweiler, Sonja
Tornillo, Luigi
Terracciano, Luigi
Meili-Butz, Silvia
Radtke, Freddy
Heim, Markus H
Semela, David
Subject(s)

600 - Technology::610...

Series
Gastroenterology
ISSN or ISBN (if monograph)
0016-5085
Publisher
Elsevier
Language
English
Publisher DOI
PubMed ID
22245843
Description
Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).
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