Comparative biodistribution of 12 ¹¹¹In-labelled gastrin/CCK2 receptor-targeting peptides

BORIS DOI
Publisher DOI
PubMed ID
21461732
Description
Cholecystokinin 2 (CCK-2) receptor overexpression has been demonstrated in various tumours such as medullary thyroid carcinomas and small-cell lung cancers. Due to this high expression, CCK-2 receptors might be suitable targets for radionuclide imaging and/or radionuclide therapy. Several CCK-2 receptor-binding radiopeptides have been developed and some have been tested in patients. Here we aimed to compare the in vivo tumour targeting properties of 12 (111)In-labelled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated gastrin/CCK2 receptor-binding peptides.
Date of Publication
2011
Publication Type
Article
Subject(s)
500 - Science::570 - Life sciences; biology
600 - Technology::610 - Medicine & health
Language(s)
en
Contributor(s)
Laverman, Peter
Joosten, Lieke
Eek, Annemarie
Roosenburg, Susan
Peitl, Petra Kolenc
Maina, Theodosia
Mäcke, Helmut
Aloj, Luigi
von Guggenberg, Elisabeth
Sosabowski, Jane K
de Jong, Marion
Oyen, Wim J G
Boerman, Otto C
Additional Credits
Institut für Pathologie
Series
European journal of nuclear medicine and molecular imaging
Publisher
Springer
ISSN
1619-7070
Access(Rights)
open.access
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