Impact of Latent Tuberculosis Infection on the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study.

BORIS DOI
Publisher DOI
PubMed ID
35172332
Description
While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV (PHIV) in the Swiss HIV Cohort Study via time-dependent cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR=1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.
Date of Publication
2022-06-15
Publication Type
Article
Subject(s)
600 - Technology::610 - Medicine & health
Keyword(s)
Heterologous immunity Inflammatory diseases Innate immunity Latent Tuberculosis Low-grade inflammation Type-2 Diabetes Mellitus
Language(s)
en
Contributor(s)
Tepekule, Burcu
Kusejko, Katharina
Zeeb, Marius
Tarr, Philip E
Calmy, Alexandra
Battegay, Manuel
Cavassini, Matthias
Bernasconi, Enos
Notter, Julia
Günthard, Huldrych F
Nemeth, Johannes
Kouyos, Roger D
Additional Credits
Universitätsklinik für Infektiologie
Series
The journal of infectious diseases
Publisher
Oxford University Press
ISSN
1537-6613
Access(Rights)
open.access
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