Tissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders.
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BORIS DOI
Date of Publication
July 25, 2021
Publication Type
Article
Division/Institute
Series
Cells
ISSN or ISBN (if monograph)
2073-4409
Publisher
MDPI
Language
English
Publisher DOI
PubMed ID
34440651
Uncontrolled Keywords
Description
Tissue-resident memory T (TRM) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, particularly in barrier tissues, but also during anti-tumor responses. However, the involvement of TRM cells also in the induction and exacerbation of immunopathologies, notably in chronically relapsing auto-inflammatory disorders, is becoming increasingly recognized as a critical factor. Thus, TRM cells may also represent an attractive target in the management of chronic (auto-) inflammatory disorders, including multiple sclerosis, rheumatoid arthritis, celiac disease and inflammatory bowel diseases. In this review, we focus on current concepts of TRM cell biology, particularly in the intestine, and discuss recent findings on their involvement in chronic relapsing-remitting inflammatory disorders. Potential therapeutic strategies to interfere with these TRM cell-mediated immunopathologies are discussed.
File(s)
File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
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cells-10-01882.pdf | text | Adobe PDF | 900.66 KB | Attribution (CC BY 4.0) | published |