Perceived health, psychological distress and quality of life in 8415 adults with congenital heart disease from 32 countries.
Options
Description
Javier Ruperti is a collaborator of 'APPROACH-IS II consortium, on behalf of the International Society for Adults Congenital Heart Disease (ISACHD)'.
BORIS DOI
Date of Publication
August 12, 2025
Publication Type
Article
Division/Institute
Author
Moons, Philip | |
Kovacs, Adrienne H | |
Goossens, Eva | |
Luyckx, Koen | |
Ladak, Laila | |
Leye, Mohamed | |
Van De Bruaene, Alexander | |
Leong, Ming Chern | |
Kaneva, Anna | |
Manso, Paulo Henrique | |
Araujo, John Jairo | |
Sasikumar, Navaneetha | |
Gabriel, Harald | |
Yadeta, Dejuma | |
Wang, Jou-Kou | |
Enomoto, Junko | |
Areias, Maria Emilia | |
Kosmidis, Diamantis | |
Coats, Louise | |
Valente, Anne Marie | |
Moon, Ju Ryoung | |
Ladouceur, Magalie | |
Jackson, Jamie L | |
Sandberg, Camilla | |
Callus, Edward | |
Kim, Yuli Y | |
Lykkeberg, Birgitte | |
Alday, Luis | |
Bredy, Charlène | |
Saidi, Arwa | |
Baraona Reyes, Fernando | |
Menahem, Samuel | |
de Hosson, Michèle | |
Hlebowicz, Joanna | |
Christersson, Christina | |
Zaidi, Ali N | |
Johansson, Bengt | |
Andresen, Brith | |
Ambassa, Jean-Claude | |
Mattsson, Eva | |
Constantine, Andrew | |
Amedro, Pascal | |
van Melle, Joost P | |
Kutty, Shelby | |
Ortiz, Lucia | |
Demir, Fatma | |
Khairy, Paul | |
Windram, Jonathan | |
Bouchardy, Judith | |
Caruana, Maryanne | |
Jameson, Susan M | |
Mahadevan, Vaikom S | |
McGrath, Lidija B | |
Mwita, Julius Chacha | |
Van Bulck, Liesbet |
Subject(s)
Series
Heart
ISSN or ISBN (if monograph)
1468-201X
1355-6037
Publisher
BMJ Publishing Group
Language
English
Publisher DOI
PubMed ID
40579213
Uncontrolled Keywords
Description
Background
The global prevalence of congenital heart disease (CHD) is increasing. Research on patient-reported outcomes (PROs) predominantly originates from high-income countries, resulting in an incomplete understanding of the true global burden of CHD from the patient perspective. Therefore, we described perceived health, psychological distress and quality of life (QoL) in a large sample of adults with CHD from the globe and explored the relationship between PROs and the income level of the countries.
Methods
Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart Disease-International Study II (APPROACH-IS II) represents an international cross-sectional investigation of PROs in 8415 patients from 53 centres across 32 countries. Patients completed questionnaires to measure perceived health status (RAND-12 Health Survey; EuroQOL-5D Visual Analog Scale); depressive symptoms (Patient Health Questionnaire-8, PHQ-8); anxiety (Generalized Anxiety Disorder Scale-7) and QoL (Linear Analog Scale). Gross National Income per capita in US dollars was used for stratifying countries according to income levels.
Results
Large intercountry disparities in PROs were observed. Switzerland demonstrated the highest mean scores for physical functioning, self-rated health and QoL, while Senegal had the lowest scores. Patients from Malta demonstrated the highest mean scores for mental health, and Senegal had the lowest scores. With regard to depressive symptoms and anxiety, Pakistan had the lowest mean scores, while Turkey had the highest scores. Patients from high-income nations reported significantly better physical functioning, mental functioning and QoL.
Conclusion
Large intercountry disparities in PROs were observed. APPROACH-IS II is a pioneering international endeavour that comprehensively evaluated PROs among adults with CHD, drawing participants from nations with different income levels.
Trial Registration Number
NCT04902768.
The global prevalence of congenital heart disease (CHD) is increasing. Research on patient-reported outcomes (PROs) predominantly originates from high-income countries, resulting in an incomplete understanding of the true global burden of CHD from the patient perspective. Therefore, we described perceived health, psychological distress and quality of life (QoL) in a large sample of adults with CHD from the globe and explored the relationship between PROs and the income level of the countries.
Methods
Assessment of Patterns of Patient-Reported Outcomes in Adults with Congenital Heart Disease-International Study II (APPROACH-IS II) represents an international cross-sectional investigation of PROs in 8415 patients from 53 centres across 32 countries. Patients completed questionnaires to measure perceived health status (RAND-12 Health Survey; EuroQOL-5D Visual Analog Scale); depressive symptoms (Patient Health Questionnaire-8, PHQ-8); anxiety (Generalized Anxiety Disorder Scale-7) and QoL (Linear Analog Scale). Gross National Income per capita in US dollars was used for stratifying countries according to income levels.
Results
Large intercountry disparities in PROs were observed. Switzerland demonstrated the highest mean scores for physical functioning, self-rated health and QoL, while Senegal had the lowest scores. Patients from Malta demonstrated the highest mean scores for mental health, and Senegal had the lowest scores. With regard to depressive symptoms and anxiety, Pakistan had the lowest mean scores, while Turkey had the highest scores. Patients from high-income nations reported significantly better physical functioning, mental functioning and QoL.
Conclusion
Large intercountry disparities in PROs were observed. APPROACH-IS II is a pioneering international endeavour that comprehensively evaluated PROs among adults with CHD, drawing participants from nations with different income levels.
Trial Registration Number
NCT04902768.
File(s)
| File | File Type | Format | Size | License | Publisher/Copright statement | Content | |
|---|---|---|---|---|---|---|---|
| heartjnl-2024-325296.full.pdf | text | Adobe PDF | 6.13 MB | published |