Associations of autozygosity with a broad range of human phenotypes.

Clark, David W; Okada, Yukinori; Moore, Kristjan H S; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L K; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M; Baumbach, Clemens; Biino, Ginevra; Bixley, Matthew J; Brumat, Marco; Chai, Jin-Fang; Corre, Tanguy; Cousminer, Diana L; Dekker, Annelot M; Eccles, David A; van Eijk, Kristel R; Fuchsberger, Christian; Gao, He; Germain, Marine; Gordon, Scott D; de Haan, Hugoline G; Harris, Sarah E; Hofer, Edith; Huerta-Chagoya, Alicia; Igartua, Catherine; Jansen, Iris E; Jia, Yucheng; Kacprowski, Tim; Karlsson, Torgny; Kleber, Marcus E; Li, Shengchao Alfred; Li-Gao, Ruifang; Mahajan, Anubha; Matsuda, Koichi; Meidtner, Karina; Meng, Weihua; Montasser, May E; van der Most, Peter J; Munz, Matthias; Nutile, Teresa; Palviainen, Teemu; Prasad, Gauri; Prasad, Rashmi B; Priyanka, Tallapragada Divya Sri; Rizzi, Federica; Salvi, Erika; Sapkota, Bishwa R; Shriner, Daniel; Skotte, Line; Smart, Melissa C; Smith, Albert Vernon; van der Spek, Ashley; Spracklen, Cassandra N; Strawbridge, Rona J; Tajuddin, Salman M; Trompet, Stella; Turman, Constance; Verweij, Niek; Viberti, Clara; Wang, Lihua; Warren, Helen R; Wootton, Robyn E; Yanek, Lisa R; Yao, Jie; Yousri, Noha A; Zhao, Wei; Adeyemo, Adebowale A; Afaq, Saima; Aguilar-Salinas, Carlos Alberto; Akiyama, Masato; Albert, Matthew L; Allison, Matthew A; Alver, Maris; Aung, Tin; Azizi, Fereidoun; Bentley, Amy R; Boeing, Heiner; Boerwinkle, Eric; Borja, Judith B; de Borst, Gert J; Bottinger, Erwin P; Broer, Linda; Campbell, Harry; Chanock, Stephen; Chee, Miao-Li; Chen, Guanjie; Chen, Yii-Der I; Chen, Zhengming; Chiu, Yen-Feng; Cocca, Massimiliano; Collins, Francis S; Concas, Maria Pina; Corley, Janie; Cugliari, Giovanni; van Dam, Rob M; Damulina, Anna; Daneshpour, Maryam S; Day, Felix R; Delgado, Graciela E; Dhana, Klodian; Doney, Alexander S F; Dörr, Marcus; Doumatey, Ayo P; Dzimiri, Nduna; Ebenesersdóttir, S Sunna; Elliott, Joshua; Elliott, Paul; Ewert, Ralf; Felix, Janine F; Fischer, Krista; Freedman, Barry I; Girotto, Giorgia; Goel, Anuj; Gögele, Martin; Goodarzi, Mark O; Graff, Mariaelisa; Granot-Hershkovitz, Einat; Grodstein, Francine; Guarrera, Simonetta; Gudbjartsson, Daniel F; Guity, Kamran; Gunnarsson, Bjarni; Guo, Yu; Hagenaars, Saskia P; Haiman, Christopher A; Halevy, Avner; Harris, Tamara B; Hedayati, Mehdi; van Heel, David A; Hirata, Makoto; Höfer, Imo; Hsiung, Chao Agnes; Huang, Jinyan; Hung, Yi-Jen; Ikram, M Arfan; Jagadeesan, Anuradha; Jousilahti, Pekka; Kamatani, Yoichiro; Kanai, Masahiro; Kerrison, Nicola D; Kessler, Thorsten; Khaw, Kay-Tee; Khor, Chiea Chuen; de Kleijn, Dominique P V; Koh, Woon-Puay; Kolcic, Ivana; Kraft, Peter; Krämer, Bernhard K; Kutalik, Zoltán; Kuusisto, Johanna; Langenberg, Claudia; Launer, Lenore J; Lawlor, Deborah A; Lee, I-Te; Lee, Wen-Jane; Lerch, Markus M; Li, Liming; Liu, Jianjun; Loh, Marie; London, Stephanie J; Loomis, Stephanie; Lu, Yingchang; Luan, Jian'an; Mägi, Reedik; Manichaikul, Ani W; Manunta, Paolo; Másson, Gísli; Matoba, Nana; Mei, Xue W; Meisinger, Christa; Meitinger, Thomas; Mezzavilla, Massimo; Milani, Lili; Millwood, Iona Y; Momozawa, Yukihide; Moore, Amy; Morange, Pierre-Emmanuel; Moreno-Macías, Hortensia; Mori, Trevor A; Morrison, Alanna C; Muka, Taulant; Murakami, Yoshinori; Murray, Alison D; de Mutsert, Renée; Mychaleckyj, Josyf C; Nalls, Mike A; Nauck, Matthias; Neville, Matt J; Nolte, Ilja M; Ong, Ken K; Orozco, Lorena; Padmanabhan, Sandosh; Pálsson, Gunnar; Pankow, James S; Pattaro, Cristian; Pattie, Alison; Polasek, Ozren; Poulter, Neil; Pramstaller, Peter P; Quintana-Murci, Lluis; Räikkönen, Katri; Ralhan, Sarju; Rao, Dabeeru C; van Rheenen, Wouter; Rich, Stephen S; Ridker, Paul M; Rietveld, Cornelius A; Robino, Antonietta; van Rooij, Frank J A; Ruggiero, Daniela; Saba, Yasaman; Sabanayagam, Charumathi; Sabater-Lleal, Maria; Sala, Cinzia Felicita; Salomaa, Veikko; Sandow, Kevin; Schmidt, Helena; Scott, Laura J; Scott, William R; Sedaghati-Khayat, Bahareh; Sennblad, Bengt; van Setten, Jessica; Sever, Peter J; Sheu, Wayne H-H; Shi, Yuan; Shrestha, Smeeta; Shukla, Sharvari Rahul; Sigurdsson, Jon K; Sikka, Timo Tonis; Singh, Jai Rup; Smith, Blair H; Stančáková, Alena; Stanton, Alice; Starr, John M; Stefansdottir, Lilja; Straker, Leon; Sulem, Patrick; Sveinbjornsson, Gardar; Swertz, Morris A; Taylor, Adele M; Taylor, Kent D; Terzikhan, Natalie; Tham, Yih-Chung; Thorleifsson, Gudmar; Thorsteinsdottir, Unnur; Tillander, Annika; Tracy, Russell P; Tusié-Luna, Teresa; Tzoulaki, Ioanna; Vaccargiu, Simona; Vangipurapu, Jagadish; Veldink, Jan H; Vitart, Veronique; Völker, Uwe; Vuoksimaa, Eero; Wakil, Salma M; Waldenberger, Melanie; Wander, Gurpreet S; Wang, Ya Xing; Wareham, Nicholas J; Wild, Sarah; Yajnik, Chittaranjan S; Yuan, Jian-Min; Zeng, Lingyao; Zhang, Liang; Zhou, Jie; Amin, Najaf; Asselbergs, Folkert W; Bakker, Stephan J L; Becker, Diane M; Lehne, Benjamin; Bennett, David A; van den Berg, Leonard H; Berndt, Sonja I; Bharadwaj, Dwaipayan; Bielak, Lawrence F; Bochud, Murielle; Boehnke, Mike; Bouchard, Claude; Bradfield, Jonathan P; Brody, Jennifer A; Campbell, Archie; Carmi, Shai; Caulfield, Mark J; Cesarini, David; Chambers, John C; Chandak, Giriraj Ratan; Cheng, Ching-Yu; Ciullo, Marina; Cornelis, Marilyn; Cusi, Daniele; Smith, George Davey; Deary, Ian J; Dorajoo, Rajkumar; van Duijn, Cornelia M; Ellinghaus, David; Erdmann, Jeanette; Eriksson, Johan G; Evangelou, Evangelos; Evans, Michele K; Faul, Jessica D; Feenstra, Bjarke; Feitosa, Mary; Foisy, Sylvain; Franke, Andre; Friedlander, Yechiel; Gasparini, Paolo; Gieger, Christian; Gonzalez, Clicerio; Goyette, Philippe; Grant, Struan F A; Griffiths, Lyn R; Groop, Leif; Gudnason, Vilmundur; Gyllensten, Ulf; Hakonarson, Hakon; Hamsten, Anders; van der Harst, Pim; Heng, Chew-Kiat; Hicks, Andrew A; Hochner, Hagit; Huikuri, Heikki; Hunt, Steven C; Jaddoe, Vincent W V; De Jager, Philip L; Johannesson, Magnus; Johansson, Åsa; Jonas, Jost B; Jukema, J Wouter; Junttila, Juhani; Kaprio, Jaakko; Kardia, Sharon L R; Karpe, Fredrik; Kumari, Meena; Laakso, Markku; van der Laan, Sander W; Lahti, Jari; Laudes, Matthias; Lea, Rodney A; Lieb, Wolfgang; Lumley, Thomas; Martin, Nicholas G; März, Winfried; Matullo, Giuseppe; McCarthy, Mark I; Medland, Sarah E; Merriman, Tony R; Metspalu, Andres; Meyer, Brian F; Mohlke, Karen L; Montgomery, Grant W; Mook-Kanamori, Dennis; Munroe, Patricia B; North, Kari E; Nyholt, Dale R; O'connell, Jeffery R; Ober, Carole; Oldehinkel, Albertine J; Palmas, Walter; Palmer, Colin; Pasterkamp, Gerard G; Patin, Etienne; Pennell, Craig E; Perusse, Louis; Peyser, Patricia A; Pirastu, Mario; Polderman, Tinca J C; Porteous, David J; Posthuma, Danielle; Psaty, Bruce M; Rioux, John D; Rivadeneira, Fernando; Rotimi, Charles; Rotter, Jerome I; Rudan, Igor; Den Ruijter, Hester M; Sanghera, Dharambir K; Sattar, Naveed; Schmidt, Reinhold; Schulze, Matthias B; Schunkert, Heribert; Scott, Robert A; Shuldiner, Alan R; Sim, Xueling; Small, Neil; Smith, Jennifer A; Sotoodehnia, Nona; Tai, E-Shyong; Teumer, Alexander; Timpson, Nicholas J; Toniolo, Daniela; Tregouet, David-Alexandre; Tuomi, Tiinamaija; Vollenweider, Peter; Wang, Carol A; Weir, David R; Whitfield, John B; Wijmenga, Cisca; Wong, Tien-Yin; Wright, John; Yang, Jingyun; Yu, Lei; Zemel, Babette S; Zonderman, Alan B; Perola, Markus; Magnusson, Patrik K E; Uitterlinden, André G; Kooner, Jaspal S; Chasman, Daniel I; Loos, Ruth J F; Franceschini, Nora; Franke, Lude; Haley, Chris S; Hayward, Caroline; Walters, Robin G; Perry, John R B; Esko, Tōnu; Helgason, Agnar; Stefansson, Kari; Joshi, Peter K; Kubo, Michiaki; Wilson, James F

doi:10.7892/boris.134574

Associations of autozygosity with a broad range of human phenotypes.

BORIS DOI

10.7892/boris.134574

Date of Publication

October 31, 2019

Publication Type

Article

Division/Institute

Institut für Sozial- ...

Author

Clark, David W
Okada, Yukinori
Moore, Kristjan H S
Mason, Dan
Pirastu, Nicola
Gandin, Ilaria
Mattsson, Hannele
Barnes, Catriona L K
Lin, Kuang
Zhao, Jing Hua
Deelen, Patrick
Rohde, Rebecca
Schurmann, Claudia
Guo, Xiuqing
Giulianini, Franco
Zhang, Weihua
Medina-Gomez, Carolina
Karlsson, Robert
Bao, Yanchun
Bartz, Traci M
Baumbach, Clemens
Biino, Ginevra
Bixley, Matthew J
Brumat, Marco
Chai, Jin-Fang
Corre, Tanguy
Cousminer, Diana L
Dekker, Annelot M
Eccles, David A
van Eijk, Kristel R
Fuchsberger, Christian
Gao, He
Germain, Marine
Gordon, Scott D
de Haan, Hugoline G
Harris, Sarah E
Hofer, Edith
Huerta-Chagoya, Alicia
Igartua, Catherine
Jansen, Iris E
Jia, Yucheng
Kacprowski, Tim
Karlsson, Torgny
Kleber, Marcus E
Li, Shengchao Alfred
Li-Gao, Ruifang
Mahajan, Anubha
Matsuda, Koichi
Meidtner, Karina
Meng, Weihua
Montasser, May E
van der Most, Peter J
Munz, Matthias
Nutile, Teresa
Palviainen, Teemu
Prasad, Gauri
Prasad, Rashmi B
Priyanka, Tallapragada Divya Sri
Rizzi, Federica
Salvi, Erika
Sapkota, Bishwa R
Shriner, Daniel
Skotte, Line
Smart, Melissa C
Smith, Albert Vernon
van der Spek, Ashley
Spracklen, Cassandra N
Strawbridge, Rona J
Tajuddin, Salman M
Trompet, Stella
Turman, Constance
Verweij, Niek
Viberti, Clara
Wang, Lihua
Warren, Helen R
Wootton, Robyn E
Yanek, Lisa R
Yao, Jie
Yousri, Noha A
Zhao, Wei
Adeyemo, Adebowale A
Afaq, Saima
Aguilar-Salinas, Carlos Alberto
Akiyama, Masato
Albert, Matthew L
Allison, Matthew A
Alver, Maris
Aung, Tin
Azizi, Fereidoun
Bentley, Amy R
Boeing, Heiner
Boerwinkle, Eric
Borja, Judith B
de Borst, Gert J
Bottinger, Erwin P
Broer, Linda
Campbell, Harry
Chanock, Stephen
Chee, Miao-Li
Chen, Guanjie
Chen, Yii-Der I
Chen, Zhengming
Chiu, Yen-Feng
Cocca, Massimiliano
Collins, Francis S
Concas, Maria Pina
Corley, Janie
Cugliari, Giovanni
van Dam, Rob M
Damulina, Anna
Daneshpour, Maryam S
Day, Felix R
Delgado, Graciela E
Dhana, Klodian
Doney, Alexander S F
Dörr, Marcus
Doumatey, Ayo P
Dzimiri, Nduna
Ebenesersdóttir, S Sunna
Elliott, Joshua
Elliott, Paul
Ewert, Ralf
Felix, Janine F
Fischer, Krista
Freedman, Barry I
Girotto, Giorgia
Goel, Anuj
Gögele, Martin
Goodarzi, Mark O
Graff, Mariaelisa
Granot-Hershkovitz, Einat
Grodstein, Francine
Guarrera, Simonetta
Gudbjartsson, Daniel F
Guity, Kamran
Gunnarsson, Bjarni
Guo, Yu
Hagenaars, Saskia P
Haiman, Christopher A
Halevy, Avner
Harris, Tamara B
Hedayati, Mehdi
van Heel, David A
Hirata, Makoto
Höfer, Imo
Hsiung, Chao Agnes
Huang, Jinyan
Hung, Yi-Jen
Ikram, M Arfan
Jagadeesan, Anuradha
Jousilahti, Pekka
Kamatani, Yoichiro
Kanai, Masahiro
Kerrison, Nicola D
Kessler, Thorsten
Khaw, Kay-Tee
Khor, Chiea Chuen
de Kleijn, Dominique P V
Koh, Woon-Puay
Kolcic, Ivana
Kraft, Peter
Krämer, Bernhard K
Kutalik, Zoltán
Kuusisto, Johanna
Langenberg, Claudia
Launer, Lenore J
Lawlor, Deborah A
Lee, I-Te
Lee, Wen-Jane
Lerch, Markus M
Li, Liming
Liu, Jianjun
Loh, Marie
London, Stephanie J
Loomis, Stephanie
Lu, Yingchang
Luan, Jian'an
Mägi, Reedik
Manichaikul, Ani W
Manunta, Paolo
Másson, Gísli
Matoba, Nana
Mei, Xue W
Meisinger, Christa
Meitinger, Thomas
Mezzavilla, Massimo
Milani, Lili
Millwood, Iona Y
Momozawa, Yukihide
Moore, Amy
Morange, Pierre-Emmanuel
Moreno-Macías, Hortensia
Mori, Trevor A
Morrison, Alanna C
Muka, Taulant	Institut für Sozial- und Präventivmedizin (ISPM)
Murakami, Yoshinori
Murray, Alison D
de Mutsert, Renée
Mychaleckyj, Josyf C
Nalls, Mike A
Nauck, Matthias
Neville, Matt J
Nolte, Ilja M
Ong, Ken K
Orozco, Lorena
Padmanabhan, Sandosh
Pálsson, Gunnar
Pankow, James S
Pattaro, Cristian
Pattie, Alison
Polasek, Ozren
Poulter, Neil
Pramstaller, Peter P
Quintana-Murci, Lluis
Räikkönen, Katri
Ralhan, Sarju
Rao, Dabeeru C
van Rheenen, Wouter
Rich, Stephen S
Ridker, Paul M
Rietveld, Cornelius A
Robino, Antonietta
van Rooij, Frank J A
Ruggiero, Daniela
Saba, Yasaman
Sabanayagam, Charumathi
Sabater-Lleal, Maria
Sala, Cinzia Felicita
Salomaa, Veikko
Sandow, Kevin
Schmidt, Helena
Scott, Laura J
Scott, William R
Sedaghati-Khayat, Bahareh
Sennblad, Bengt
van Setten, Jessica
Sever, Peter J
Sheu, Wayne H-H
Shi, Yuan
Shrestha, Smeeta
Shukla, Sharvari Rahul
Sigurdsson, Jon K
Sikka, Timo Tonis
Singh, Jai Rup
Smith, Blair H
Stančáková, Alena
Stanton, Alice
Starr, John M
Stefansdottir, Lilja
Straker, Leon
Sulem, Patrick
Sveinbjornsson, Gardar
Swertz, Morris A
Taylor, Adele M
Taylor, Kent D
Terzikhan, Natalie
Tham, Yih-Chung
Thorleifsson, Gudmar
Thorsteinsdottir, Unnur
Tillander, Annika
Tracy, Russell P
Tusié-Luna, Teresa
Tzoulaki, Ioanna
Vaccargiu, Simona
Vangipurapu, Jagadish
Veldink, Jan H
Vitart, Veronique
Völker, Uwe
Vuoksimaa, Eero
Wakil, Salma M
Waldenberger, Melanie
Wander, Gurpreet S
Wang, Ya Xing
Wareham, Nicholas J
Wild, Sarah
Yajnik, Chittaranjan S
Yuan, Jian-Min
Zeng, Lingyao
Zhang, Liang
Zhou, Jie
Amin, Najaf
Asselbergs, Folkert W
Bakker, Stephan J L
Becker, Diane M
Lehne, Benjamin
Bennett, David A
van den Berg, Leonard H
Berndt, Sonja I
Bharadwaj, Dwaipayan
Bielak, Lawrence F
Bochud, Murielle
Boehnke, Mike
Bouchard, Claude
Bradfield, Jonathan P
Brody, Jennifer A
Campbell, Archie
Carmi, Shai
Caulfield, Mark J
Cesarini, David
Chambers, John C
Chandak, Giriraj Ratan
Cheng, Ching-Yu
Ciullo, Marina
Cornelis, Marilyn
Cusi, Daniele
Smith, George Davey
Deary, Ian J
Dorajoo, Rajkumar
van Duijn, Cornelia M
Ellinghaus, David
Erdmann, Jeanette
Eriksson, Johan G
Evangelou, Evangelos
Evans, Michele K
Faul, Jessica D
Feenstra, Bjarke
Feitosa, Mary
Foisy, Sylvain
Franke, Andre
Friedlander, Yechiel
Gasparini, Paolo
Gieger, Christian
Gonzalez, Clicerio
Goyette, Philippe
Grant, Struan F A
Griffiths, Lyn R
Groop, Leif
Gudnason, Vilmundur
Gyllensten, Ulf
Hakonarson, Hakon
Hamsten, Anders
van der Harst, Pim
Heng, Chew-Kiat
Hicks, Andrew A
Hochner, Hagit
Huikuri, Heikki
Hunt, Steven C
Jaddoe, Vincent W V
De Jager, Philip L
Johannesson, Magnus
Johansson, Åsa
Jonas, Jost B
Jukema, J Wouter
Junttila, Juhani
Kaprio, Jaakko
Kardia, Sharon L R
Karpe, Fredrik
Kumari, Meena
Laakso, Markku
van der Laan, Sander W
Lahti, Jari
Laudes, Matthias
Lea, Rodney A
Lieb, Wolfgang
Lumley, Thomas
Martin, Nicholas G
März, Winfried
Matullo, Giuseppe
McCarthy, Mark I
Medland, Sarah E
Merriman, Tony R
Metspalu, Andres
Meyer, Brian F
Mohlke, Karen L
Montgomery, Grant W
Mook-Kanamori, Dennis
Munroe, Patricia B
North, Kari E
Nyholt, Dale R
O'connell, Jeffery R
Ober, Carole
Oldehinkel, Albertine J
Palmas, Walter
Palmer, Colin
Pasterkamp, Gerard G
Patin, Etienne
Pennell, Craig E
Perusse, Louis
Peyser, Patricia A
Pirastu, Mario
Polderman, Tinca J C
Porteous, David J
Posthuma, Danielle
Psaty, Bruce M
Rioux, John D
Rivadeneira, Fernando
Rotimi, Charles
Rotter, Jerome I
Rudan, Igor
Den Ruijter, Hester M
Sanghera, Dharambir K
Sattar, Naveed
Schmidt, Reinhold
Schulze, Matthias B
Schunkert, Heribert
Scott, Robert A
Shuldiner, Alan R
Sim, Xueling
Small, Neil
Smith, Jennifer A
Sotoodehnia, Nona
Tai, E-Shyong
Teumer, Alexander
Timpson, Nicholas J
Toniolo, Daniela
Tregouet, David-Alexandre
Tuomi, Tiinamaija
Vollenweider, Peter
Wang, Carol A
Weir, David R
Whitfield, John B
Wijmenga, Cisca
Wong, Tien-Yin
Wright, John
Yang, Jingyun
Yu, Lei
Zemel, Babette S
Zonderman, Alan B
Perola, Markus
Magnusson, Patrik K E
Uitterlinden, André G
Kooner, Jaspal S
Chasman, Daniel I
Loos, Ruth J F
Franceschini, Nora
Franke, Lude
Haley, Chris S
Hayward, Caroline
Walters, Robin G
Perry, John R B
Esko, Tōnu
Helgason, Agnar
Stefansson, Kari
Joshi, Peter K
Kubo, Michiaki
Wilson, James F

Subject(s)

600 - Technology::610...

300 - Social sciences...

Series

Nature communications

ISSN or ISBN (if monograph)

2041-1723

Publisher

Nature Publishing Group

Language

English

Publisher DOI

10.1038/s41467-019-12283-6

PubMed ID

31673082

Description

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.

Handle

https://boris-portal.unibe.ch/handle/20.500.12422/182958

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Associations of autozygosity with a broad range of human phenotypes.

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