Use of sedation-awakening electroencephalography in dogs with epilepsy.
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BORIS DOI
Publisher DOI
PubMed ID
39133769
Description
BACKGROUND
Electroencephalography (EEG) recording protocols have been standardized for humans. Although the utilization of techniques in veterinary medicine is increasing, a standard protocol has not yet been established.
HYPOTHESIS
Assessment of a sedation-awakening EEG protocol in dogs.
ANIMALS
Electroencephalography examination was performed in a research colony of 6 nonepileptic dogs (control [C]) and 12 dogs with epilepsy admitted to the clinic because of the epileptic seizures.
METHODS
It was a prospective study with retrospective control. Dogs with epilepsy were divided into 2 equal groups, wherein EEG acquisition was performed using a "sedation" protocol (IE-S, n = 6) and a "sedation-awakening" protocol (IE-SA, n = 6). All animals were sedated using medetomidine. In IE-SA group, sedation was reversed 5 minutes after commencing the EEG recording by injecting atipamezole IM. Type of background activity (BGA) and presence of EEG-defined epileptiform discharges (EDs) were evaluated blindly. Statistical significance was set at P > 0.05.
RESULTS
Epileptiform discharges were found in 1 of 6 of the dogs in group C, 4 of 6 of the dogs in IE-S group, and 5 of 6 of the dogs in IE-SA group. A significantly greater number of EDs (spikes, P = .0109; polyspikes, P = .0109; sharp waves, P = .01) were detected in Phase 2 in animals subjected to the "sedation-awakening" protocol, whereas there was no statistically significant greater number of discharges in sedated animals.
CONCLUSIONS AND CLINICAL IMPORTANCE
A "sedation-awakening" EEG protocol could be of value for ambulatory use if repeated EEG recordings and monitoring of epilepsy in dogs is needed.
Electroencephalography (EEG) recording protocols have been standardized for humans. Although the utilization of techniques in veterinary medicine is increasing, a standard protocol has not yet been established.
HYPOTHESIS
Assessment of a sedation-awakening EEG protocol in dogs.
ANIMALS
Electroencephalography examination was performed in a research colony of 6 nonepileptic dogs (control [C]) and 12 dogs with epilepsy admitted to the clinic because of the epileptic seizures.
METHODS
It was a prospective study with retrospective control. Dogs with epilepsy were divided into 2 equal groups, wherein EEG acquisition was performed using a "sedation" protocol (IE-S, n = 6) and a "sedation-awakening" protocol (IE-SA, n = 6). All animals were sedated using medetomidine. In IE-SA group, sedation was reversed 5 minutes after commencing the EEG recording by injecting atipamezole IM. Type of background activity (BGA) and presence of EEG-defined epileptiform discharges (EDs) were evaluated blindly. Statistical significance was set at P > 0.05.
RESULTS
Epileptiform discharges were found in 1 of 6 of the dogs in group C, 4 of 6 of the dogs in IE-S group, and 5 of 6 of the dogs in IE-SA group. A significantly greater number of EDs (spikes, P = .0109; polyspikes, P = .0109; sharp waves, P = .01) were detected in Phase 2 in animals subjected to the "sedation-awakening" protocol, whereas there was no statistically significant greater number of discharges in sedated animals.
CONCLUSIONS AND CLINICAL IMPORTANCE
A "sedation-awakening" EEG protocol could be of value for ambulatory use if repeated EEG recordings and monitoring of epilepsy in dogs is needed.
Date of Publication
2024-08-12
Publication Type
Article
Subject(s)
600 - Technology::630 - Agriculture
Keyword(s)
ambulatory EEG canine electroencephalography canine epilepsy diagnosis epilepsy paroxysmal sedation seizure
Language(s)
en
Contributor(s)
Wrzosek, Marcin | |
Banasik, Aleksandra | |
Czerwik, Adriana | |
Olszewska, Agnieszka | |
Płonek, Marta |
Additional Credits
Departement für klinische Veterinärmedizin - Klinische Neurologie
Series
Journal of veterinary internal medicine
Publisher
Wiley
ISSN
1939-1676
Access(Rights)
open.access