Histological evaluation of nonsurgical periodontal treatment with and without the use of sodium hypochlorite / amino acids and cross-linked hyaluronic acid gels in dogs.
Options
BORIS DOI
Publisher DOI
PubMed ID
38676852
Description
OBJECTIVES
To evaluate periodontal wound healing following scaling and root planing (SRP) in conjunction with the application of sodium hypochlorite/amino acids and cross-linked hyaluronic acid (xHyA) gels in dogs.
MATERIALS AND METHODS
In four beagle dogs, 2-wall intrabony defects were created and metal strips were placed around the teeth. Clinical parameters were measured 4 weeks after plaque accumulation. The experimental root surfaces were subjected to SRP with either the subgingival application of a sodium hypochlorite/amino acid gel and a xHyA gel (test group) or SRP alone (control group) using a split-mouth design. Clinical parameters were re-evaluated at 6 weeks. The animals were sacrificed at 8 weeks for histological analysis.
RESULTS
The test group showed significant improvements in all clinical parameters compared to the control group. Histologically, the test group exhibited statistically significantly greater new bone formation [i.e., length of newly formed bone, new bone area] compared with the control group (p < 0.05). Furthermore, statistically significantly greater formation of new attachment [i.e., linear length of new cementum adjacently to newly formed bone with inserting collagen fibers] and new cementum was detected in the test group compared with the control group at 8 weeks (p < 0.05 and p < 0.01, respectively).
CONCLUSION
The adjunctive subgingival application of sodium hypochlorite/amino acid and xHyA gels to SRP offers an innovative novel approach to enhance periodontal wound healing/regeneration.
CLINICAL RELEVANCE
The present findings have for the first-time shown histologic evidence for periodontal regeneration in support of this novel treatment modality.
To evaluate periodontal wound healing following scaling and root planing (SRP) in conjunction with the application of sodium hypochlorite/amino acids and cross-linked hyaluronic acid (xHyA) gels in dogs.
MATERIALS AND METHODS
In four beagle dogs, 2-wall intrabony defects were created and metal strips were placed around the teeth. Clinical parameters were measured 4 weeks after plaque accumulation. The experimental root surfaces were subjected to SRP with either the subgingival application of a sodium hypochlorite/amino acid gel and a xHyA gel (test group) or SRP alone (control group) using a split-mouth design. Clinical parameters were re-evaluated at 6 weeks. The animals were sacrificed at 8 weeks for histological analysis.
RESULTS
The test group showed significant improvements in all clinical parameters compared to the control group. Histologically, the test group exhibited statistically significantly greater new bone formation [i.e., length of newly formed bone, new bone area] compared with the control group (p < 0.05). Furthermore, statistically significantly greater formation of new attachment [i.e., linear length of new cementum adjacently to newly formed bone with inserting collagen fibers] and new cementum was detected in the test group compared with the control group at 8 weeks (p < 0.05 and p < 0.01, respectively).
CONCLUSION
The adjunctive subgingival application of sodium hypochlorite/amino acid and xHyA gels to SRP offers an innovative novel approach to enhance periodontal wound healing/regeneration.
CLINICAL RELEVANCE
The present findings have for the first-time shown histologic evidence for periodontal regeneration in support of this novel treatment modality.
Date of Publication
2024-04-27
Publication Type
Article
Subject(s)
600 - Technology::610 - Medicine & health
Keyword(s)
Cross-linked hyaluronic acid Non-surgical periodontal therapy Periodontal wound healing/regeneration Periodontitis Sodium hypochlorite/amino acids
Language(s)
en
Contributor(s)
Shirakata, Yoshinori | |
Nakamura, Toshiaki | |
Setoguchi, Fumiaki | |
Imafuji, Takatomo | |
Shinohara, Yukiya | |
Matsumura, Shohei | |
Iwata, Masayuki | |
Noguchi, Kazuyuki | |
Ramanauskaite, Eglė |
Additional Credits
Zahnmedizinische Kliniken (ZMK) Universität Bern
Series
Clinical oral investigations
Publisher
Springer
ISSN
1436-3771
Access(Rights)
open.access