The role of interleukin-15 in the development and treatment of hematological malignancies.

BORIS DOI
Publisher DOI
PubMed ID
37153603
Description
Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers.
Date of Publication
2023
Publication Type
Article
Subject(s)
600 - Technology::610 - Medicine & health
Keyword(s)
IL-15 blood cancer cytokine treatment
Language(s)
en
Contributor(s)
Pandey, Hritisha
Isabelle, Colleen
Chakravarti, Nitin
Brammer, Jonathan Edward
Porcu, Pierluigi
Mishra, Anjali
Additional Credits
Universitätsklinik für Hämatologie und Hämatologisches Zentrallabor
Series
Frontiers in immunology
Publisher
Frontiers Research Foundation
ISSN
1664-3224
Access(Rights)
open.access
Show full item