Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges-The Hamburg perspective.

BORIS DOI
Publisher DOI
PubMed ID
36875015
Description
Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational power of cardiovascular research. Importantly they should allow to study genetic effects on an electrophysiological background close to the human situation. However, biological and methodological issues revealed when human induced pluripotent stem cell-derived cardiomyocytes were used in experimental electrophysiology. We will discuss some of the challenges that should be considered when human induced pluripotent stem cell-derived cardiomyocytes will be used as a physiological model.
Date of Publication
2023
Publication Type
Article
Subject(s)
600 - Technology::610 - Medicine & health
Keyword(s)
action potentials automated patch clamp computer modelling and simulation hESC-CM hiPSC-CM human cardiomyocytes ion currents
Language(s)
en
Contributor(s)
Ismaili, Djemail
Schulz, Carl
Koivumäki, Jussi T
Mika, Delphine
Hansen, Arne
Eschenhagen, Thomas
Christ, Torsten
Additional Credits
Institut für Physiologie
Series
Frontiers in physiology
Publisher
Frontiers Research Foundation
ISSN
1664-042X
Access(Rights)
open.access
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