Post-acute phase and sequelae management of epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus.

BORIS DOI
Publisher DOI
PubMed ID
36814255
Description
BACKGROUND

Long-term sequelae are frequent and often disabling after epidermal necrolysis (Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)). However, consensus on the modalities of management of these sequelae is lacking.

OBJECTIVES

We conducted an international multicentric DELPHI exercise to establish a multidisciplinary expert consensus to standardize recommendations regarding management of SJS/TEN sequelae.

METHODS

Participants were sent a survey via the online tool "Survey Monkey" consisting of 54 statements organized into 8 topics: general recommendations, professionals involved, skin, oral mucosa and teeth, eyes, genital area, mental health, and allergy workup. Participants evaluated the level of appropriateness of each statement on a scale of 1 (extremely inappropriate) to 9 (extremely appropriate). Results were analyzed according to the RAND/UCLA Appropriateness Method.

RESULTS

Fifty-two healthcare professionals participated. After the first round, a consensus was obtained for 100% of 54 initially proposed statements (disagreement index < 1). Among them, 50 statements were agreed upon as 'appropriate'; four statements were considered 'uncertain', and ultimately finally discarded.

CONCLUSIONS

Our DELPHI-based expert consensus should help guide physicians in conducting a prolonged multidisciplinary follow-up of sequelae in SJS-TEN.
Date of Publication
2023-02-22
Publication Type
article
Subject(s)
600 - Technology::610 - Medicine & health
Keyword(s)
Consensus Delphi Epidermal necrolysis Quality of life Sequelae Stevens-Johnson syndrome Toxic epidermal necrolysis
Language(s)
en
Contributor(s)
Ingen-Housz-Oro, S
Schmidt, V
Ameri, M M
Abe, R
Brassard, A
Mostaghimi, A
Paller, A S
Romano, A
Didona, B
Kaffenberger, B H
Ben Said, B
Thong, B Y H
Ramsay, B
Brezinova, E
Milpied, B
Mortz, C G
Chu, C Y
Sotozono, C
Gueudry, J
Fortune, D G
Dridi, S M
Tartar, D
Do-Pham, G
Gabison, E
Phillips, E J
Lewis, F
Salavastru, C
Horvath, B
Dart, J
Setterfield, J
Newman, J
Schulz, J T
Delcampe, A
Brockow, K
Seminario-Vidal, L
Watson, M P
Gonçalo, M
Lucas, M
Torres, M
Noe, M H
Hama, N
Shear, N H
O'Reilly, P
Wolkenstein, P
Romanelli, P
Dodiuk-Gad, R P
Micheletti, R G
Tiplica, G S
Sheridan, R
Rauz, S
Ahmad, S
Chua, S L
Flynn, T H
Pichler, W
Le, S T
Maverakis, E
Walsh, S
French, L E
Brüggen, M C
Additional Credits
Universitätsklinik für Pneumologie und Allergologie
Series
Orphanet journal of rare diseases
Publisher
BioMed Central
ISSN
1750-1172
Access(Rights)
open.access
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