Current concepts in eosinophilic esophagitis.
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BORIS DOI
Publisher DOI
PubMed ID
29104849
Description
Background
Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration.
Methods
This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE.
Results
EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization. Barrier dysfunction and T‑helper 2 inflammation are considered to be pathogenetically important factors. Recently, a proton pump inhibitor (PPI)-sensitive EoE subtype as well as an EoE-like disorder have been described.
Conclusion
Research in recent years has contributed to a better understanding of the disease spectrum and pathogenesis of EoE, including genetic dispositions, thereby laying the foundation for innovative treatment approaches.
Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration.
Methods
This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE.
Results
EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization. Barrier dysfunction and T‑helper 2 inflammation are considered to be pathogenetically important factors. Recently, a proton pump inhibitor (PPI)-sensitive EoE subtype as well as an EoE-like disorder have been described.
Conclusion
Research in recent years has contributed to a better understanding of the disease spectrum and pathogenesis of EoE, including genetic dispositions, thereby laying the foundation for innovative treatment approaches.
Date of Publication
2017
Publication Type
Article
Subject(s)
600 - Technology::610 - Medicine & health
Keyword(s)
Barrier dysfunction Diet Eosinophilic esophagitis Eosinophils T‑helper 2 inflammation
Language(s)
en
Contributor(s)
Straumann, Alex | |
Schoepfer, Alain M |
Additional Credits
Institut für Pharmakologie
Universitätsklinik für Dermatologie
Series
Allergo journal international
Publisher
Springer
ISSN
2197-0378
Access(Rights)
open.access