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Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences.

BORIS DOI
Publisher DOI
PubMed ID
27469626
Description
Considering the 3R rules of animal experimentation, we asked if refined scoring of experimental autoimmune encephalomyelitis (EAE) in mice improves documentation of clinical EAE allowing to perform a more powerful statistical analysis. Surprisingly, refined EAE scoring failed to improve statistical outcome comparing the overall disease courses between two groups of mice.
Date of Publication
2016-10
Publication Type
Article
Subject(s)
Keyword(s)
Area under the curve
•
Bland-Altman plots
•
Clinical scoring
•
Experimental autoimmune encephalomyelitis
•
Statistical analysis
Language(s)
en
Contributor(s)
Additional Credits
Series
European journal of immunology
Publisher
Wiley-VCH
ISSN
0014-2980
Access(Rights)
open.access
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