Novel genetic loci associated with hippocampal volume

BORIS DOI
Publisher DOI
PubMed ID
28098162
Description
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes
(ASTN2, DPP4and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease (rg = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
Date of Publication
2017
Publication Type
Article
Subject(s)
100 - Philosophy::150 - Psychology
600 - Technology::610 - Medicine & health
Language(s)
en
Contributor(s)
Hibar, Derrek P.
Hieab, H.H. Adams
Chauhan, Ganesh
Stein, Jason L.
Hofer, Edith
Renteria, Miguel E.
Bis, Joshua
Arias-Vasquez, Alejandro
Ikram, Kamran
Desrivières, Sylvane
Vernooij, Meike W.
Abramovic, Lucija
Alhusaini, Saud
Amin, Najaf
Andersson, Micael
Arfanakis, Konstantinos A.
Aribisala, Benjamin S.
Armstrong, Nicola J.
Athanasiu, Lavinia
Axelsson, Tomas
Beecham, Ashley H.
Beiser, Alexa
Bernard, Manon
Blanton, Susan H.
Bohlken, Marc M.
Boks, Marco P.
Bralten, Janita
Brickman, Adam M.
Carmichael, Owen
Chakravarty, M. Mallar
Chen, Qiang
Ching, Christopher R.K.
Chouraki, Vincent
Cuellar-Partida, Gabriel
Crivello, Fabrice
Den Braber, Anouk
Doan, Nhat Trung
Ehrlich, Stefan
Giddaluru, Sudheer
Goldman, Aaron L.
Gottesman, Rebecca F.
Grimm, Oliver
Griswold, Michael E.
Guadalupe, Tulio
Gutman, Boris A.
Hass, Johanna
Haukvik, Unn K.
Höhn, David
Holmes, Avram J.
Hoogman, Martine
Janowitz, Deborah
Jia, Tianye
Jørgensen, Kjetil N.
Karbalai, Nazanin
Kasperaviciute, Dalia
Kim, Sungeun
Klein, Marieke
Kraemer, Bernd
Lee, Phil H.
Liewald, David C.M.
Lopez, Lorna M.
Luciano, Michelle
Macare, Christine
Marquand, Andre
Matarin, Mar
Mather, Karen A.
Mattheisen, Manuel
McKay, David R.
Milaneschi, Yuri
Munoz Maniega, Susanna
Nho, Kwangsik
Nugent, Allison C.
Nyquist, Paul
Olde Loohuis, Loes M.
Oosterlaan, Jaap
Pirpamer, Lukas
Pütz, Benno
Ramasamy, Adaikalavan
Richards, Jennifer S.
Risacher, Shannon L.
Roiz-Santianez, Roberto
Rommelse, Nanda
Ropele, Stefan
Rose, Emma J.
Royle, Natalie A.
Rundek, Tatjana
Sämann, Philipp G.
Saremi, Arvin
Satizabal, Claudia L.
Schmaal, Lianne
Schork, Andrew J.
Shen, Li
Shin, Jean
Shumskaya, Elena
Smith, Albert V.
Sprooten, Emma
Strike, Lachlan T.
Teumer, Alexander
Tordesillas-Gutierrez, Diana
Toro, Roberto
Trabzuni, Daniah
Trompet, Stella
Vaidya, Dhananjay
Van der Grond, Jeroen
Van der Lee, Sven J.
Van der Meer, Dennis
Van Donkelaar, Marjolein M.J.
Van Eijk, Kristel R.
Van Erp, Theo G.M.
Van Rooij, Daan
Walton, Esther
Westlye, Lars T.
Whelan, Christopher D.
Windham, Beverly G.
Winkler, Anderson M.
Wittfeld, Katharina
Woldehawariat, Girma
Wolf, Christiane
Wolfers, Thomas
Yanek, Lisa R.
Yang, Jingyun
Zijdenbos, Alex
Zwiers, Marcel P.
Agartz, Ingrid
Almasy, Laura
Ames, David
Amouyel, Philippe
Andreassen, Ole A.
Arepalli, Sampath
Assareh, Amelia A.
Barral, Sandra
Bastin, Mark E.
Becker, Diane M.
Becker, James T.
Bennett, David A.
Blangero, John
van Bokhoven, Hans
Boomsma, Dorret I.
Brodaty, Henry
Brouwer, Rachel M.
Brunner, Han G.
Buckner, Randy L.
Buitelaar, Jan K.
Bulayeva, Kazima B.
Cahn, Wiepke
Calhoun, Vince D.
Cannon, Dara M.
Cavalleri, Gianpiero L.
Cheng, Ching-Yu
Cichon, Sven
Cookson, Mark R.
Corvin, Aiden
Crespo-Facorro, Benedicto
Curran, Joanne E.
Czisch, Michael
Dale, Anders M.
Davies, Gareth E.
De Craen, Anton J.M.
De Geus, Eco J.C.
De Jager, Philip L.
De Zubicaray, Greig I.
Deary, Ian J.
Debette, Stéphanie
DeCarli, Charles
Delanty, Norman
Depondt, Chantal
DeStefano, Anita
Dillman, Allissa
Djurovic, Srdjan
Donohoe, Gary
Drevets, Wayne C.
Duggirala, Ravi
Dyer, Thomas D.
Enzinger, Christian
Erk, Susanne
Espeseth, Thomas
Fedko, Iryna O.
Fernandez, Guillén
Ferrucci, Luigi
Fisher, Simon E.
Fleischman, Debra A.
Ford, Ian
Fornage, Myriam
Foroud, Tatiana M.
Fox, Peter T.
Francks, Clyde
Fukunaga, Masaki
Gibbs, J. Raphael
Glahn, David C.
Gollub, Randy L.
Göring, Harald H.H.
Green, Robert C.
Gruber, Oliver
Gudnason, Vilmundur
Guelfi, Sebastian
Håberg, Asta K.
Hansell, Narelle K.
Hardy, John
Hartman, Catharina A.
Hashimoto, Ryota
Hegenscheid, Katrin
Heinz, Andreas
Le Hellard, Stephanie
Hernandez, Dena G.
Heslenfeld, Dirk J.
Ho, Beng-Choon
Hoekstra, Pieter J.
Hoffmann, Wolfgang
Hofman, Albert
Holsboer, Florian
Homuth, Georg
Hosten, Norbert
Hottenga, Jouke-Jan
Huentelman, Matthew
Hulshoff Pol, Hilleke E.
Ikeda, Masashi
Jack, Clifford R.
Jenkinson, Mark
Johnson, Robert
Jönsson, Erik G.
Jukema, J. Wouter
Kahn, René S.
Kanai, Ryota
Kloszewska, Iwona
Knopman, David S.
Kochunov, Peter
Kwok, John B.
Lawrie, Stephen M.
Lemaıtre, Hervé
Liu, Xinmin
Longo, Dan L.
Lopez, Oscar L.
Lopez, Oscar L.
Lovestone, Simon
Martinez, Oliver
Martinot, Jean-Luc
Mattay, Venkata S.
McDonald, Colm
McIntosh, Andrew M.
McMahon, Francis J.
McMahon, Katie L.
Mecocci, Patrizia
Melle, Ingrid
Meyer-Lindenberg, Andreas
Mohnke, Sebastian
Montgomery, Grant W.
Morris, Derek W.
Mosley, Thomas H.
Mühleisen, Thomas W.
Müller-Myhsok, Bertram
Nalls, Michael A.
Nauck, Matthias
Nichols, Thomas E.
Niessen, Wiro J.
Nöthen, Markus M.
Nyberg, Lars
Ohi, Kazutaka
Olvera, Rene L.
Ophoff, Roel A.
Pandolfo, Massimo
Paus, Tomas
Pausova, Zdenka
Penninx, Brenda W.J.H.
Pike, G. Bruce
Potkin, Steven G.
Psaty, Bruce M.
Reppermund, Simone
Rietschel, Marcella
Roffman, Joshua L.
Romanczuk-Seiferth, Nina
Rotter, Jerome I.
Ryten, Mina
Sacco, Ralph L.
S. Sachdev, Perminder
Saykin, Andrew J.
Schmidt, Reinhold
Schmidt, Helena
Schofield, Peter R.
Sigursson, Sigurdur
Simmons, Andy
Singleton, Andrew
Sisodiya, Sanjay M.
Smith, Colin
Smoller, Jordan W.
Soininen, Hilkka
Steen, Vidar M.
Stott, David J.
Sussmann, Jessika E.
Thalamuthu, Anbupalam
Toga, Arthur W.
Traynor, Bryan
Troncoso, Juan
Tsolaki, Magda
Tzourio, Christophe
Uitterlinden, Andre G.
Valdés-Hernandez, Maria C.
Van der Brug, Marcel
Van der Lugt, Aad
Van der Wee, Nic J.A.
Van Haren, Neeltje E.M.
Van’t Ent, Dennis
Van Tol, Marie-Jose
Vardarajan, Badri N.
Vellas, Bruno
Veltman, Dick J.
Völzke, Henry
Walter, Henrik
Wardlaw, Joanna M.
Wassink, Thomas H.
Weale, Michael E.
Weinberger, Daniel R.
Weiner, Michael W.
Wen, Wei
Westman, Eric
White, Tonya
Wong, Tien Y.
Wright, Clinton B.
Zielke, Ronald H.
Zonderman, Alan B.
Martin, Nicholas G.
Van Duijn, Cornelia M.
Wright, Margaret J.
Longstreth, W.T.
Schumann, Gunter
Grabe, Hans J.
Franke, Barbara
Launer, Lenore J.
Medland, Sarah E.
Seshadri, Sudha
Thompson, Paul M.
Ikram, M. Arfan
Additional Credits
Zentrum für Translationale Forschung der Universitätsklinik für Psychiatrie und Psychotherapie
Series
Nature communications
Publisher
Nature Publishing Group
ISSN
2041-1723
Access(Rights)
open.access
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