Does menopause transition influence viral suppression and adherence in Women living with HIV?
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BORIS DOI
Publisher DOI
PubMed ID
36595226
Description
BACKGROUND
Increasing numbers of women living with HIV transition through menopause. It is unclear if this transition has an impact on treatment adherence, viral suppression, psychiatric comorbidities or drug use. We aimed at examining adherence and viral suppression during the perimenopausal period and explored the influence of psychiatric comorbidities and active injection drug use (IDU).
SETTING
Retrospective Swiss HIV Cohort Study analysis from 01/2010 to 12/2018.
METHODS
We explored peri- and postmenopausal trends of viral blips, low-level viremia, viral failure, adherence, psychiatric comorbidities and IDU using interrupted time series (ITS) models.
RESULTS
Rates of depression and psychiatric care increased during perimenopause before decreasing afterwards. Negative treatment outcomes such as viral blips, low-level viremia, viral failure and low adherence steadily declined while transitioning through menopause - this was also true for subgroups of women with depression, psychiatric treatment and active IDU.
CONCLUSIONS
Increased rates of depression and psychiatric care while transitioning through menopause do not result in lower rates of adherence or viral suppression in women living with HIV in Switzerland.
Increasing numbers of women living with HIV transition through menopause. It is unclear if this transition has an impact on treatment adherence, viral suppression, psychiatric comorbidities or drug use. We aimed at examining adherence and viral suppression during the perimenopausal period and explored the influence of psychiatric comorbidities and active injection drug use (IDU).
SETTING
Retrospective Swiss HIV Cohort Study analysis from 01/2010 to 12/2018.
METHODS
We explored peri- and postmenopausal trends of viral blips, low-level viremia, viral failure, adherence, psychiatric comorbidities and IDU using interrupted time series (ITS) models.
RESULTS
Rates of depression and psychiatric care increased during perimenopause before decreasing afterwards. Negative treatment outcomes such as viral blips, low-level viremia, viral failure and low adherence steadily declined while transitioning through menopause - this was also true for subgroups of women with depression, psychiatric treatment and active IDU.
CONCLUSIONS
Increased rates of depression and psychiatric care while transitioning through menopause do not result in lower rates of adherence or viral suppression in women living with HIV in Switzerland.
Date of Publication
2023-04-15
Publication Type
Article
Subject(s)
Language(s)
en
Contributor(s)
Calmy, A | |
Tarr, P E | |
Darling, K E A | |
Babouee Flury, B | |
Polli, C | |
Sultan-Beyer, L | |
Abela, I A |
Series
Journal of acquired immune deficiency syndromes
Publisher
Wolters Kluwer Health
ISSN
1944-7884
Access(Rights)
open.access