Peptides and peptide dendrimers as drug delivery and anticancer agents
BORIS DOI
Abstract
Peptides are compounds, that are involved in a wide range of biological applications. Use of peptides in cancer therapy can become an alternative strategy to conventional chemotherapy, which is often complicated by increased resistance and detrimental side effects. In the beginning of this thesis, a general introduction gives short overview of current problems of cancer treatment (Chapter 1). The experimental work is divided into two parts. In the first part, we investigated peptides and peptide dendrimers as possible delivery vectors for chemotherapy drugs such as doxorubicin and 1,2-diaminocyclohexane-Platinum(II) (Chapters 2 and 3). We designed suitable drug delivery strategies and assessed the anticancer activity of conjugates.
In the second part, we aimed to develop different peptidic molecules, which can directly act as anticancer agents. By using machine learning approaches, we generated linear, non-hemolytic anticancer peptides (Chapter 4). Further biological evaluations revealed membranolytic and mitochondria targeting properties of selected anticancer peptides. In the Chapter 5 we reported for the first time anticancer properties of peptide dendrimers and presented our attempts to build peptide dendrimers with so-called “isopeptide bonds”.
In the second part, we aimed to develop different peptidic molecules, which can directly act as anticancer agents. By using machine learning approaches, we generated linear, non-hemolytic anticancer peptides (Chapter 4). Further biological evaluations revealed membranolytic and mitochondria targeting properties of selected anticancer peptides. In the Chapter 5 we reported for the first time anticancer properties of peptide dendrimers and presented our attempts to build peptide dendrimers with so-called “isopeptide bonds”.
Date of Publication
2022
Year of graduation
2022
Theses Type
dissertation
Subject(s)
Language(s)
en
Author(s)
Zakharova, Elena |
Faculty/Graduate School
Access(Rights)
open.access
Primary OA Publication
true