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Differential effects of anti-hypertensive treatment on the retinal microcirculation: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub- study

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dc.contributor.authorThom, S
dc.contributor.authorStettler, Christoph
dc.contributor.authorStanton, A
dc.contributor.authorWitt, N
dc.contributor.authorTapp, R
dc.contributor.authorChaturvedi, N
dc.contributor.authorAllemann, Sabin
dc.contributor.authorMayet, J
dc.contributor.authorSever, P
dc.contributor.authorPoulter, N
dc.contributor.authorO'Brien, E
dc.contributor.authorHughes, A
dc.date.accessioned2024-10-14T07:54:24Z
dc.date.available2024-10-14T07:54:24Z
dc.date.issued2009
dc.description.abstractChanges in the retinal microcirculation are associated with hypertension and predict cardiovascular mortality. There are few data describing the impact of antihypertensive therapy on retinal vascular changes. This substudy of the Anglo-Scandinavian Cardiac Outcomes Trial compared the effects of an amlodipine-based regimen (373 patients) with an atenolol-based regimen (347 patients) on retinal microvascular measurements made from fundus photographs. The retinal photographs were taken at a stage in the trial when treatments were stable and blood pressure was well controlled. Amlodipine-based treatment was associated with a smaller arteriolar length:diameter ratio than atenolol-based treatment (13.32 [10.75 to 16.04] versus 14.12 [11.27 to 17.81], median [interquartile range]; P<0.01). The association remained significant after adjustment for age, sex, cholesterol, systolic and diastolic blood pressures, body mass index, smoking, and statin treatment. This effect appeared to be largely attributable to shorter retinal arteriolar segment lengths in the amlodipine-treated group and is best explained by the vasodilator effects of amlodipine causing the visible emergence of branching side vessels. Photographic assessment of the retinal vascular network may be a useful approach to evaluating microvascular structural responses in clinical trials of antihypertensive therapy.
dc.description.numberOfPages4
dc.description.sponsorshipUniversitätspoliklinik für Endokrinologie, Diabetologie und Klinische Ernährung
dc.identifier.doi10.7892/boris.32486
dc.identifier.isi000268250300039
dc.identifier.pmid19528363
dc.identifier.publisherDOI10.1161/HYPERTENSIONAHA.109.133819
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/105917
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.publisher.placePhiladelphia, Pa.
dc.relation.ispartofHypertension
dc.relation.issn0194-911X
dc.relation.organizationDCD5A442C012E17DE0405C82790C4DE2
dc.titleDifferential effects of anti-hypertensive treatment on the retinal microcirculation: an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub- study
dc.typearticle
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oaire.citation.endPage408
oaire.citation.issue2
oaire.citation.startPage405
oaire.citation.volume54
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oairecerif.author.affiliationUniversitätspoliklinik für Endokrinologie, Diabetologie und Klinische Ernährung
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oairecerif.author.affiliationUniversitätspoliklinik für Endokrinologie, Diabetologie und Klinische Ernährung
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unibe.eprints.legacyId32486
unibe.journal.abbrevTitleHYPERTENSION
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