Publication:
Anticholinergic and Sedative Medications Are Associated With Neurocognitive Performance of Well Treated People With Human Immunodeficiency Virus.

cris.virtualsource.author-orcidc1e12329-42c6-4bb3-b744-61f4114c3555
cris.virtualsource.author-orcid6f78ea45-f2e9-4ba8-a7aa-1848f070af29
datacite.rightsopen.access
dc.contributor.authorJakeman, Bernadette
dc.contributor.authorScherrer, Alexandra U
dc.contributor.authorDarling, Katharine E A
dc.contributor.authorDamas, Jose
dc.contributor.authorBieler-Aeschlimann, Melanie
dc.contributor.authorHasse, Barbara
dc.contributor.authorSchlosser, Ladina
dc.contributor.authorHachfeld, Anna
dc.contributor.authorGutbrod, Klemens
dc.contributor.authorTarr, Philip E
dc.contributor.authorCalmy, Alexandra
dc.contributor.authorAssal, Frederic
dc.contributor.authorKunze, Ursula
dc.contributor.authorStoeckle, Marcel
dc.contributor.authorSchmid, Patrick
dc.contributor.authorToller, Gianina
dc.contributor.authorRossi, Stefania
dc.contributor.authordi Benedetto, Caroline
dc.contributor.authordu Pasquier, Renaud
dc.contributor.authorCavassini, Matthias
dc.contributor.authorMarzolini, Catia
dc.date.accessioned2024-10-11T17:16:51Z
dc.date.available2024-10-11T17:16:51Z
dc.date.issued2022-09
dc.description.abstractBackground We previously showed that anticholinergic (ACH) medications contribute to self-reported neurocognitive impairment (NCI) in elderly people with human immunodeficiency virus (PWH). The current cross-sectional study further evaluated the effect of ACH and sedative drugs on neurocognitive function in PWH who underwent comprehensive neuropsychological evaluation. Methods A medication review was performed in PWH enrolled in the prospective Neurocognitive Assessment in Metabolic and Aging Cohort within the Swiss HIV Cohort Study. Neurocognitive functions were analyzed in 5 domains (motor skills, speed of information, attention/working memory, executive functions, and verbal learning memory). The effect of ACH and sedative medications on neurocognitive functioning was evaluated using linear regression models for the continuous (mean z-score) outcome and multivariable logistic regression models for the binary (presence/absence) outcome. Results A total of 963 PWH (80% male, 92% Caucasian, 96% virologically suppressed, median age 52) were included. Fourteen percent of participants were prescribed ≥1 ACH medication and 9% were prescribed ≥1 sedative medication. Overall, 40% of participants had NCI. Sedative medication use was associated with impaired attention/verbal learning and ACH medication use with motor skills deficits both in the continuous (mean z-score difference -0.26 to -0.14, P < .001 and P = .06) and binary (odds ratio [OR], ≥1.67; P < .05) models. Their combined use was associated with deficits in overall neurocognitive functions in both models (mean z-score difference -0.12, P = .002 and OR = 1.54, P = .03). These associations were unchanged in a subgroup analysis of participants without depression (n = 824). Conclusions Anticholinergic and sedative medications contribute to NCI. Clinicians need to consider these drugs when assessing NCI in PWH.
dc.description.numberOfPages8
dc.description.sponsorshipUniversitätsklinik für Infektiologie
dc.description.sponsorshipUniversitätsklinik für Neurologie
dc.identifier.doi10.48350/173226
dc.identifier.pmid36147598
dc.identifier.publisherDOI10.1093/ofid/ofac457
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/87686
dc.language.isoen
dc.publisherOxford University Press
dc.relation.ispartofOpen Forum Infectious Diseases
dc.relation.issn2328-8957
dc.relation.organizationDCD5A442BAE0E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BB13E17DE0405C82790C4DE2
dc.subjectHIV anticholinergic medication neuro-HIV neurocognitive impairment sedative medication
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleAnticholinergic and Sedative Medications Are Associated With Neurocognitive Performance of Well Treated People With Human Immunodeficiency Virus.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue9
oaire.citation.startPageofac457
oaire.citation.volume9
oairecerif.author.affiliationUniversitätsklinik für Infektiologie
oairecerif.author.affiliationUniversitätsklinik für Neurologie
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unibe.date.licenseChanged2022-09-26 12:35:19
unibe.description.ispublishedpub
unibe.eprints.legacyId173226
unibe.journal.abbrevTitleOpen Forum Infectious Diseases
unibe.refereedtrue
unibe.subtype.articlejournal

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