Publication: Anticholinergic and Sedative Medications Are Associated With Neurocognitive Performance of Well Treated People With Human Immunodeficiency Virus.
cris.virtualsource.author-orcid | c1e12329-42c6-4bb3-b744-61f4114c3555 | |
cris.virtualsource.author-orcid | 6f78ea45-f2e9-4ba8-a7aa-1848f070af29 | |
datacite.rights | open.access | |
dc.contributor.author | Jakeman, Bernadette | |
dc.contributor.author | Scherrer, Alexandra U | |
dc.contributor.author | Darling, Katharine E A | |
dc.contributor.author | Damas, Jose | |
dc.contributor.author | Bieler-Aeschlimann, Melanie | |
dc.contributor.author | Hasse, Barbara | |
dc.contributor.author | Schlosser, Ladina | |
dc.contributor.author | Hachfeld, Anna | |
dc.contributor.author | Gutbrod, Klemens | |
dc.contributor.author | Tarr, Philip E | |
dc.contributor.author | Calmy, Alexandra | |
dc.contributor.author | Assal, Frederic | |
dc.contributor.author | Kunze, Ursula | |
dc.contributor.author | Stoeckle, Marcel | |
dc.contributor.author | Schmid, Patrick | |
dc.contributor.author | Toller, Gianina | |
dc.contributor.author | Rossi, Stefania | |
dc.contributor.author | di Benedetto, Caroline | |
dc.contributor.author | du Pasquier, Renaud | |
dc.contributor.author | Cavassini, Matthias | |
dc.contributor.author | Marzolini, Catia | |
dc.date.accessioned | 2024-10-11T17:16:51Z | |
dc.date.available | 2024-10-11T17:16:51Z | |
dc.date.issued | 2022-09 | |
dc.description.abstract | Background We previously showed that anticholinergic (ACH) medications contribute to self-reported neurocognitive impairment (NCI) in elderly people with human immunodeficiency virus (PWH). The current cross-sectional study further evaluated the effect of ACH and sedative drugs on neurocognitive function in PWH who underwent comprehensive neuropsychological evaluation. Methods A medication review was performed in PWH enrolled in the prospective Neurocognitive Assessment in Metabolic and Aging Cohort within the Swiss HIV Cohort Study. Neurocognitive functions were analyzed in 5 domains (motor skills, speed of information, attention/working memory, executive functions, and verbal learning memory). The effect of ACH and sedative medications on neurocognitive functioning was evaluated using linear regression models for the continuous (mean z-score) outcome and multivariable logistic regression models for the binary (presence/absence) outcome. Results A total of 963 PWH (80% male, 92% Caucasian, 96% virologically suppressed, median age 52) were included. Fourteen percent of participants were prescribed ≥1 ACH medication and 9% were prescribed ≥1 sedative medication. Overall, 40% of participants had NCI. Sedative medication use was associated with impaired attention/verbal learning and ACH medication use with motor skills deficits both in the continuous (mean z-score difference -0.26 to -0.14, P < .001 and P = .06) and binary (odds ratio [OR], ≥1.67; P < .05) models. Their combined use was associated with deficits in overall neurocognitive functions in both models (mean z-score difference -0.12, P = .002 and OR = 1.54, P = .03). These associations were unchanged in a subgroup analysis of participants without depression (n = 824). Conclusions Anticholinergic and sedative medications contribute to NCI. Clinicians need to consider these drugs when assessing NCI in PWH. | |
dc.description.numberOfPages | 8 | |
dc.description.sponsorship | Universitätsklinik für Infektiologie | |
dc.description.sponsorship | Universitätsklinik für Neurologie | |
dc.identifier.doi | 10.48350/173226 | |
dc.identifier.pmid | 36147598 | |
dc.identifier.publisherDOI | 10.1093/ofid/ofac457 | |
dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/87686 | |
dc.language.iso | en | |
dc.publisher | Oxford University Press | |
dc.relation.ispartof | Open Forum Infectious Diseases | |
dc.relation.issn | 2328-8957 | |
dc.relation.organization | DCD5A442BAE0E17DE0405C82790C4DE2 | |
dc.relation.organization | DCD5A442BB13E17DE0405C82790C4DE2 | |
dc.subject | HIV anticholinergic medication neuro-HIV neurocognitive impairment sedative medication | |
dc.subject.ddc | 600 - Technology::610 - Medicine & health | |
dc.title | Anticholinergic and Sedative Medications Are Associated With Neurocognitive Performance of Well Treated People With Human Immunodeficiency Virus. | |
dc.type | article | |
dspace.entity.type | Publication | |
dspace.file.type | text | |
oaire.citation.issue | 9 | |
oaire.citation.startPage | ofac457 | |
oaire.citation.volume | 9 | |
oairecerif.author.affiliation | Universitätsklinik für Infektiologie | |
oairecerif.author.affiliation | Universitätsklinik für Neurologie | |
unibe.contributor.role | creator | |
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unibe.date.licenseChanged | 2022-09-26 12:35:19 | |
unibe.description.ispublished | pub | |
unibe.eprints.legacyId | 173226 | |
unibe.journal.abbrevTitle | Open Forum Infectious Diseases | |
unibe.refereed | true | |
unibe.subtype.article | journal |
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