Neurological complications of rotavirus infection in children: a systematic review and meta-analysis.
Publisher DOI
PubMed ID
36951625
Abstract
AIM
To systematically review the clinical features and outcomes of pediatric patients developing neurological complications associated with a rotavirus infection.
METHODS
A systematic literature review and meta-analysis was performed, including articles published from 1984 to 2020. Neurological complications were classified into four groups: encephalitis, cerebellitis, encephalo-cerebellitis and benign convulsions with mild gastroenteritis (CwG).
RESULTS
Out of 68 reports that fulfilled the research criteria, 99 cases of CwG, 39 cases of encephalitis, 18 cases of encephalo-cerebellitis and five cases of cerebellitis were collected. Ninety-five patients were from Asia. Median age was 22 (IQR 14-29) months, and the children who developed CwG were significantly younger (19, IQR 12-24 months, p<0.0001) than the others. Status epilepticus was observed in 23% and 5% of the encephalitis and CwG groups, respectively. The most frequently described neuroimaging finding were lesions of the splenium of corpus callosum. Four deaths were reported in the encephalitis group, whereas no fatal events were described in the other groups. Among the surviving children, the encephalo-cerebellitis group showed the most severe long-term outcome. All cases of CwG recovered completely.
CONCLUSION
Older age at diagnosis and the development of encephalo-cerebellitis are associated with a higher risk of long-term complications.
To systematically review the clinical features and outcomes of pediatric patients developing neurological complications associated with a rotavirus infection.
METHODS
A systematic literature review and meta-analysis was performed, including articles published from 1984 to 2020. Neurological complications were classified into four groups: encephalitis, cerebellitis, encephalo-cerebellitis and benign convulsions with mild gastroenteritis (CwG).
RESULTS
Out of 68 reports that fulfilled the research criteria, 99 cases of CwG, 39 cases of encephalitis, 18 cases of encephalo-cerebellitis and five cases of cerebellitis were collected. Ninety-five patients were from Asia. Median age was 22 (IQR 14-29) months, and the children who developed CwG were significantly younger (19, IQR 12-24 months, p<0.0001) than the others. Status epilepticus was observed in 23% and 5% of the encephalitis and CwG groups, respectively. The most frequently described neuroimaging finding were lesions of the splenium of corpus callosum. Four deaths were reported in the encephalitis group, whereas no fatal events were described in the other groups. Among the surviving children, the encephalo-cerebellitis group showed the most severe long-term outcome. All cases of CwG recovered completely.
CONCLUSION
Older age at diagnosis and the development of encephalo-cerebellitis are associated with a higher risk of long-term complications.
Date Issued
2023-07
Publication Type
Article
Subject(s)
Subjects
CwG cerebellitis convulsions encephalitis gastroenteritis rotavirus
Language(s)
en
Author(s)
Meyer, A | |
Mazzara, C | |
Lava, S A G | |
Treglia, G | |
Bianchetti, M G | |
Simonetti, G D |
Additional Credits
Journal
Acta paediatrica
Publisher
Wiley
ISSN
1651-2227
Access(Rights)
open.access