Publication:
Green oxygen power plants in the brain rescue neuronal activity.

cris.virtualsource.author-orcid67095b8d-92a8-4b98-8c20-a3d9c63edebc
datacite.rightsopen.access
dc.contributor.authorÖzugur, Suzan
dc.contributor.authorChavez Rosas, Myra Noemi
dc.contributor.authorSanchez-Gonzalez, Rosario
dc.contributor.authorKunz, Lars
dc.contributor.authorNickelsen, Jörg
dc.contributor.authorStraka, Hans
dc.date.accessioned2024-10-06T19:09:18Z
dc.date.available2024-10-06T19:09:18Z
dc.date.issued2021-10-22
dc.description.abstractNeuronal activity in the brain depends on mostly aerobic generation of energy equivalents and thus on a constant O2 supply. Oxygenation of the vertebrate brain has been optimized during evolution by species-specific uptake and transport of O2 that originally derives from the phototrophic activity of prokaryotic and eukaryotic organisms in the environment. Here, we employed a concept that exploits transcardial injection and vascular distribution of unicellular green algae or cyanobacteria in the brain of Xenopus laevis tadpoles. Using oxygen measurements in the brain ventricle, we found that these microorganisms robustly produce sizable amounts of O2 upon illumination. In a severe hypoxic environment, when neuronal activity has completely ceased, the photosynthetic O2 reliably provoked a restart and rescue of neuronal activity. In the future, phototrophic microorganisms might provide a novel means to directly increase oxygen levels in the brain in a controlled manner under particular eco-physiological conditions or following pathological impairments.
dc.description.numberOfPages16
dc.description.sponsorshipInstitut für Anatomie, Entwicklungsbiologie und Regeneration
dc.identifier.doi10.48350/162211
dc.identifier.pmid34755084
dc.identifier.publisherDOI10.1016/j.isci.2021.103158
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/58265
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofiScience
dc.relation.issn2589-0042
dc.relation.organizationDCD5A442BD6AE17DE0405C82790C4DE2
dc.subjectBiotechnology Classification Description: Animal physiology Microbiology Neuroscience
dc.titleGreen oxygen power plants in the brain rescue neuronal activity.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue10
oaire.citation.startPage103158
oaire.citation.volume24
oairecerif.author.affiliationInstitut für Anatomie, Entwicklungsbiologie und Regeneration
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
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unibe.date.licenseChanged2022-01-04 12:35:04
unibe.description.ispublishedpub
unibe.eprints.legacyId162211
unibe.refereedtrue
unibe.subtype.articlejournal

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