Current Prospects and Future Directions of Single Time Point Dosimetry in Radiopharmaceutical Therapy: A Systematic Review.

The rise of image-based approaches has reshaped personalized dosimetry in radiopharmaceutical therapies, holding the promise of reducing organ toxicity and tailoring treatments to individual responses. However, implementing these strategies accurately demands numerous quantitative scans and complex data processing, posing significant clinical hurdles. Therefore, simplified methodologies like single-time point (STP) dosimetry have emerged, aiming to enhance efficiency in clinical dosimetry. STP dosimetry estimates absorbed doses in radiopharmaceutical therapy from a singular measurement of time-integrated activity (TIA) at a specific time point. Following the PRISMA guidelines, a systematic exploration was performed on PubMed, ScienceDirect, Scopus, and Web of Science. This review encompasses research concentrating on organ dosimetry in patients employing STP dosimetry from January 2012 to December 2023. Evaluation of these chosen articles exposes a variety of uses for STP dosimetry, outlining its theoretical bases, practical applications, and discussions regarding its vital role in achieving a balance between eliminating tumors and reducing exposure to healthy tissues. From this review, STP dosimetry offers a hopeful path in simplifying personalized dosimetry by decreasing imaging intervals without sacrificing its accuracy. This innovative approach holds potential for routine dosimetry in clinical settings, potentially revolutionizing the landscape of radiopharmaceutical therapy.