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Therapy-Related Acute Myeloid Leukemia after CAR-T Cell Therapy with Brexucabtagene Autoleucel for Mantle Cell Lymphoma.

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cris.virtual.author-orcid0000-0003-4474-3132
cris.virtualsource.author-orcidd3fcb446-375d-473f-afbb-fcb815a020d3
cris.virtualsource.author-orcidc441561b-2f62-41ef-8e09-fb335467e1b9
cris.virtualsource.author-orcid62fb166c-c73f-4e79-b474-ba5d778eb98c
cris.virtualsource.author-orcidd8f42926-f873-4a1f-839a-49eecd87333a
cris.virtualsource.author-orcid347baa39-8b2d-408d-922e-c504789f6476
cris.virtualsource.author-orcid87c04196-fbb6-42b8-97bf-151846fee8ea
cris.virtualsource.author-orcid3ffc609d-4653-413a-a80f-2bf6c2b71f47
cris.virtualsource.author-orcid1b65be99-ede2-4b0e-8e6d-1c720e453513
datacite.rightsopen.access
dc.contributor.authorVolery, François
dc.contributor.authorBanz, Yara
dc.contributor.authorHeini, Alexander
dc.contributor.authorKronig, Marie-Noëlle
dc.contributor.authorSiegrist, Daniel
dc.contributor.authorDaskalakis, Michael
dc.contributor.authorBacher, Ulrike
dc.contributor.authorPabst, Thomas
dc.date.accessioned2024-11-08T09:42:31Z
dc.date.available2024-11-08T09:42:31Z
dc.date.issued2024
dc.description.abstractIntroduction The introduction of CAR-T cell treatment for relapsed/refractory (r/r) mantle cell lymphoma improved survival rates of these patients. Along with its introduction in clinical routine, long-term events after CAR-T cell treatment are increasingly emerging.Case Presentation We report the case of a patient developing acute erythroid leukemia with biallelic TP53 inactivation occurring 26 months after CAR-T therapy with brexucabtagene autoleucel (brexu-cel) for r/r mantle cell lymphoma. The patient presented with a healthy bone marrow prior to lymphoma treatments.Discussion Secondary malignancies seem more frequent after CAR-T therapies. More studies are needed to assess potential long-term toxicities of CAR-T cell therapies including the frequency of secondary myeloid malignancies.
dc.description.sponsorshipClinic of Medical Oncology
dc.description.sponsorshipInstitute of Tissue Medicine and Pathology, Clinical Pathology
dc.description.sponsorshipClinic of Haematology and Central Haematological Laboratory
dc.description.sponsorshipDepartment for BioMedical Research, Forschungsgruppe Hämatologie (Erwachsene)
dc.identifier.doi10.48620/76115
dc.identifier.pmid39474550
dc.identifier.publisherDOI10.1159/000541256
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/188820
dc.language.isoen
dc.publisherKarger Publishers
dc.relation.ispartofCase Reports in Oncology
dc.relation.issn1662-6575
dc.subjectAcute erythroid leukemia
dc.subjectAcute myeloid leukemia
dc.subjectBrexucabtagene autoleucel
dc.subjectCAR-T
dc.subjectMantle cell lymphoma
dc.titleTherapy-Related Acute Myeloid Leukemia after CAR-T Cell Therapy with Brexucabtagene Autoleucel for Mantle Cell Lymphoma.
dc.typearticle
dspace.entity.typePublication
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oaire.citation.endPage1093
oaire.citation.issue1
oaire.citation.startPage1087
oaire.citation.volume17
oairecerif.author.affiliationClinic of Medical Oncology
oairecerif.author.affiliationInstitute of Tissue Medicine and Pathology, Clinical Pathology
oairecerif.author.affiliationClinic of Medical Oncology
oairecerif.author.affiliationClinic of Medical Oncology
oairecerif.author.affiliationClinic of Haematology and Central Haematological Laboratory
oairecerif.author.affiliationDepartment for BioMedical Research, Forschungsgruppe Hämatologie (Erwachsene)
oairecerif.author.affiliationClinic of Haematology and Central Haematological Laboratory
oairecerif.author.affiliationClinic of Medical Oncology
oairecerif.author.affiliation2Institute of Tissue Medicine and Pathology
oairecerif.author.affiliation2Clinic of Haematology and Central Haematological Laboratory
oairecerif.author.affiliation2Department for BioMedical Research (DBMR)
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unibe.contributor.rolecorresponding author
unibe.description.ispublishedpub
unibe.refereedtrue
unibe.subtype.articlecontribution

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