Motor dysfunction in NF1: Mediated by attention deficit or inherent to the disorder?
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BORIS DOI
Publisher DOI
PubMed ID
29111114
Description
AIM
Attention deficit and compromised motor skills are both prevalent in Neurofibromatosis type 1 (NF1), but the relationship is unclear. We investigated motor function in children with NF1 and in children with Attention Deficit/Hyperactivity Disorder (ADHD), and explored if, in patients with NF1, attention deficit influences motor performance.
METHODS
Motor performance was measured using the Movement Assessment Battery for Children (M-ABC) in 71 children (26 with NF1 plus ADHD, 14 with NF1 without ADHD, and 31 with ADHD without NF1) aged 6-12 years.
RESULTS
There was a significant effect of group on motor performance. Both NF1 groups scored below children with ADHD without NF1. Attention performance mediated motor performance in children with ADHD without NF1, but not in children with NF1.
CONCLUSIONS
Motor function is not mediated by attention performance in children with NF1. While in ADHD, attention deficit influences motor performance, motor problems in NF1 seem to be independent from attention deficit. This argues for different pathomechanisms in these two groups of developmental disorders.
Attention deficit and compromised motor skills are both prevalent in Neurofibromatosis type 1 (NF1), but the relationship is unclear. We investigated motor function in children with NF1 and in children with Attention Deficit/Hyperactivity Disorder (ADHD), and explored if, in patients with NF1, attention deficit influences motor performance.
METHODS
Motor performance was measured using the Movement Assessment Battery for Children (M-ABC) in 71 children (26 with NF1 plus ADHD, 14 with NF1 without ADHD, and 31 with ADHD without NF1) aged 6-12 years.
RESULTS
There was a significant effect of group on motor performance. Both NF1 groups scored below children with ADHD without NF1. Attention performance mediated motor performance in children with ADHD without NF1, but not in children with NF1.
CONCLUSIONS
Motor function is not mediated by attention performance in children with NF1. While in ADHD, attention deficit influences motor performance, motor problems in NF1 seem to be independent from attention deficit. This argues for different pathomechanisms in these two groups of developmental disorders.
Date of Publication
2018-01
Publication Type
Article
Keyword(s)
Attention deficit Attention deficit- /hyperactivity disorder (ADHD) M-ABC Motor deficits Motor skills Neurofibromatosis type 1 (NF1)
Language(s)
en
Contributor(s)
Haas-Lude, Karin | |
Heimgärtner, Magdalena | |
Winter, Sarah | |
Mautner, Victor-Felix | |
Krägeloh-Mann, Ingeborg |
Additional Credits
Series
European journal of paediatric neurology
Publisher
Elsevier
ISSN
1090-3798
Access(Rights)
restricted