Publication:
Tissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders.

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cris.virtual.author-orcid0000-0001-7340-3861
cris.virtual.author-orcid0000-0002-3921-8678
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcide0132b95-585a-4383-b9eb-3cb1d91ac479
cris.virtualsource.author-orcidd81010df-1b8d-4998-805a-b8f9a8c4ff7e
cris.virtualsource.author-orcid280f4a57-ab98-4998-8ca7-5570fcd5c921
dc.contributor.authorBarreto de Albuquerque, Juliana
dc.contributor.authorMüller, Christoph
dc.contributor.authorGungor, Bilgi
dc.date.accessioned2024-10-06T18:48:21Z
dc.date.available2024-10-06T18:48:21Z
dc.date.issued2021-07-25
dc.description.abstractTissue-resident memory T (TRM) cells critically contribute to the rapid immunoprotection and efficient immunosurveillance against pathogens, particularly in barrier tissues, but also during anti-tumor responses. However, the involvement of TRM cells also in the induction and exacerbation of immunopathologies, notably in chronically relapsing auto-inflammatory disorders, is becoming increasingly recognized as a critical factor. Thus, TRM cells may also represent an attractive target in the management of chronic (auto-) inflammatory disorders, including multiple sclerosis, rheumatoid arthritis, celiac disease and inflammatory bowel diseases. In this review, we focus on current concepts of TRM cell biology, particularly in the intestine, and discuss recent findings on their involvement in chronic relapsing-remitting inflammatory disorders. Potential therapeutic strategies to interfere with these TRM cell-mediated immunopathologies are discussed.
dc.description.sponsorshipInstitut für Pathologie, Immunpathologie
dc.identifier.doi10.48350/161345
dc.identifier.pmid34440651
dc.identifier.publisherDOI10.3390/cells10081882
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/57639
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofCells
dc.relation.issn2073-4409
dc.relation.organizationDCD5A442BF89E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442C252E17DE0405C82790C4DE2
dc.subjectT cell retention circulating T cells intestinal inflammation memory T cells tissue-resident T cells
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleTissue-Resident T Cells in Chronic Relapsing-Remitting Intestinal Disorders.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue8
oaire.citation.volume10
oairecerif.author.affiliationInstitut für Pathologie, Immunpathologie
oairecerif.author.affiliationInstitut für Pathologie, Immunpathologie
oairecerif.author.affiliationInstitut für Pathologie, Immunpathologie
oairecerif.author.affiliation2#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation2Institut für Pathologie
oairecerif.author.affiliation2Institut für Pathologie
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation3#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation4#PLACEHOLDER_PARENT_METADATA_VALUE#
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.contributor.rolecreator
unibe.date.licenseChanged2021-11-18 14:13:23
unibe.description.ispublishedpub
unibe.eprints.legacyId161345
unibe.refereedTRUE
unibe.subtype.articlereview

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