Pyrrolidino-DNA
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BORIS DOI
Publisher DOI
PubMed ID
14565376
Description
We synthesized pyrrolidino-C-nucleosides, incorporated them into oligodeoxynucleotides and investigated their pairing properties. The thermal duplex and triplex stabilities were measured. While triplex formation is destabilized in the case of pyrrolidino-pseudo-U and -T, pyrrolidino-pseudo-iso-C leads to an increase of the Tm value for third strand dissociation. Duplexes are destabilized with all pyrrolidino-C-nucleosides
Date of Publication
2003
Publication Type
Article
Subject(s)
Keyword(s)
analogs & derivatives
chemical synthesis
chemistry
Cytosine
DNA
duplex
DUPLEXES
Indicators and Reagents
Kinetics
Oligodeoxynucleotides
OLIGODEOXYRIBONUCLEOTIDES
PAIRING PROPERTIES
properties
Pyrrolidines
pyrrolidino-DNA
stability
thermal
Thermodynamics
Triplex
Uracil
chemical synthesis
chemistry
Cytosine
DNA
duplex
DUPLEXES
Indicators and Reagents
Kinetics
Oligodeoxynucleotides
OLIGODEOXYRIBONUCLEOTIDES
PAIRING PROPERTIES
properties
Pyrrolidines
pyrrolidino-DNA
stability
thermal
Thermodynamics
Triplex
Uracil
Language(s)
en
Additional Credits
Series
Nucleosides, nucleotides & nucleic acids
Publisher
Taylor & Francis
ISSN
1525-7770
Access(Rights)
restricted