Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19.
Publisher DOI
PubMed ID
38572798
Abstract
INTRODUCTION
Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT.
PATIENTS AND METHODS
This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex.
RESULTS
We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2-4] vs 2 [1-3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7-20] vs 8 [4-15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3-16] vs 7/206 [3%, 2-7], aOR 2.6 [95% CI 0.7-9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0-2; 45/58 [78%, 95% CI 65-86] vs 161/185 [87%, 81-91], aOR 0.5 [95% CI 0.2-1.02]).
CONCLUSION
In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.
Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT.
PATIENTS AND METHODS
This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex.
RESULTS
We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2-4] vs 2 [1-3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7-20] vs 8 [4-15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3-16] vs 7/206 [3%, 2-7], aOR 2.6 [95% CI 0.7-9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0-2; 45/58 [78%, 95% CI 65-86] vs 161/185 [87%, 81-91], aOR 0.5 [95% CI 0.2-1.02]).
CONCLUSION
In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.
Date Issued
2024-09
Publication Type
Article
Subject(s)
Subjects
COVID-19 Cerebral venous thrombosis stroke
Language(s)
en
Author(s)
van de Munckhof, Anita | |
Miraclin, Angel T | |
Aaron, Sanjith | |
Hameed, Sajid | |
Wasay, Mohammad | |
Grosu, Oxana | |
Krzywicka, Katarzyna | |
Sánchez van Kammen, Mayte | |
Lindgren, Erik | |
Moreira, Tiago | |
Acampora, Roberto | |
Negro, Alberto | |
Karapanayiotides, Theodoros | |
Yaghi, Shadi | |
Revert, Anna | |
Cuadrado Godia, Elisa | |
Garcia-Madrona, Sebastian | |
La Spina, Paolino | |
Grillo, Francesco | |
Giammello, Fabrizio | |
Nguyen, Thanh N | |
Abdalkader, Mohamad | |
Buture, Alina | |
Sofia Cotelli, Maria | |
Raposo, Nicolas | |
Tsivgoulis, Georgios | |
Candelaresi, Paolo | |
Ciacciarelli, Antonio | |
Mbroh, Joshua | |
Batenkova, Tatiana | |
Scoppettuolo, Pasquale | |
Zedde, Marialuisa | |
Pascarella, Rosario | |
Kristoffersen, Espen S | |
Jood, Katarina | |
Aguiar de Sousa, Diana | |
Poli, Sven | |
Tatlisumak, Turgut | |
Putaala, Jukka | |
Coutinho, Jonathan M | |
Ferro, José M |
Journal
European stroke journal
Publisher
Sage
ISSN
2396-9881
Access(Rights)
restricted