Publication:
Neuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart

cris.virtual.author-orcid0000-0002-0905-6399
cris.virtualsource.author-orcid79bc2168-817a-44ea-be31-b11af4269ff4
datacite.rightsopen.access
dc.contributor.authorLowe, Vanessa
dc.contributor.authorWisniewski, Laura
dc.contributor.authorSayers, Jacob
dc.contributor.authorEvans, Ian
dc.contributor.authorFrankel, Paul
dc.contributor.authorMercader Huber, Nadia Isabel
dc.contributor.authorZachary, Ian C.
dc.contributor.authorPellet-Many, Caroline
dc.date.accessioned2024-10-28T17:42:53Z
dc.date.available2024-10-28T17:42:53Z
dc.date.issued2019
dc.description.abstractUnlike adult mammals, zebrafish can regenerate their heart. A key mechanism for regeneration is the activation of the epicardium, leading to the establishment of a supporting scaffold for new cardiomyocytes, angiogenesis and cytokine secretion. Neuropilins are co-receptors that mediate signaling of kinase receptors for cytokines with crucial roles in zebrafish heart regeneration. We investigated the role of neuropilins in response to cardiac injury and heart regeneration. All four neuropilin isoforms (nrp1a, nrp1b, nrp2a and nrp2b) were upregulated by the activated epicardium and an nrp1a-knockout mutant showed a significant delay in heart regeneration and displayed persistent collagen deposition. The regenerating hearts of nrp1a mutants were less vascularized, and epicardial-derived cell migration and re-expression of the developmental gene wt1b was impaired. Moreover, cryoinjury-induced activation and migration of epicardial cells in heart explants were reduced in nrp1a mutants. These results identify a key role for Nrp1 in zebrafish heart regeneration, mediated through epicardial activation, migration and revascularization.
dc.description.numberOfPages13
dc.description.sponsorshipInstitut für Anatomie
dc.identifier.doi10.7892/boris.135529
dc.identifier.pmid31167777
dc.identifier.publisherDOI10.1242/dev.174482
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/183629
dc.language.isoen
dc.publisherCompany of Biologists Limited
dc.relation.ispartofDevelopment
dc.relation.issn0950-1991
dc.relation.organizationDCD5A442BCD7E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BD6AE17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.titleNeuropilin 1 mediates epicardial activation and revascularization in the regenerating zebrafish heart
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue13
oaire.citation.volume146
oairecerif.author.affiliationInstitut für Anatomie
oairecerif.author.affiliation2Institut für Anatomie, Entwicklungsbiologie und Regeneration
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unibe.date.licenseChanged2019-12-10 14:09:13
unibe.description.ispublishedpub
unibe.eprints.legacyId135529
unibe.journal.abbrevTitleDEVELOPMENT
unibe.refereedtrue
unibe.subtype.articlejournal

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