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Nationwide Implementation of Pathogen Inactivation for All Platelet Concentrates in Switzerland.

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cris.virtualsource.author-orcid5f5278c3-d908-45fe-8a4a-885030ed281d
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dc.contributor.authorJutzi, Markus
dc.contributor.authorMansouri Taleghani, Behrouz
dc.contributor.authorRueesch, Morven
dc.contributor.authorAmsler, Lorenz
dc.contributor.authorBuser, Andreas
dc.date.accessioned2024-10-08T15:19:35Z
dc.date.available2024-10-08T15:19:35Z
dc.date.issued2018-05
dc.description.abstractIntroduction Bacterial contamination of platelet concentrates (PCs) has been identified as the most prevalent transfusion-associated infectious risk. To prevent PC-related septic transfusion reactions, the Intercept® pathogen inactivation procedure was introduced for all PCs in Switzerland in 2011. Methods Based on numbers of transfused units and mandatorily reported adverse events with high imputability, we compare the risks associated with transfusion of conventional PCs (cPCs) and pathogen-inactivated PCs (PI-PCs). Results From 2005 to 2011, a total of 158,502 cPCs have been issued in Switzerland, and 16 transfusion-transmitted bacterial infections (including 3 fatalities) were reported. This corresponds to a morbidity and mortality rate of ca. 1:9,900 and 1:52,800, respectively. From 2011 to 2016, a total of 205,574 PI-PCs have been issued, and no transfusion-transmitted bacterial infection was reported. Despite continuously increasing transfusion reaction rates per 1,000 RBC and plasma issued between 2008 and 2016, we observed reductions of 66% for life-threatening and fatal reactions and of 26% for all high-imputability transfusion reactions related to PI-PCs as compared to cPCs. No increased rates of bleeding or clinical observations of ineffectiveness of PI-PCs have been reported. After implementation of PI-PCs, the annual increase in platelet usage per 1,000 inhabitants decelerated. Discussion Swiss hemovigilance data confirm a favorable safety profile of the nationwide introduced Intercept pathogen inactivation procedure and its reliable prevention of septic transfusion reactions and fatalities due to bacterially contaminated PCs.
dc.description.numberOfPages6
dc.description.sponsorshipUniversitätsklinik für Hämatologie und Hämatologisches Zentrallabor
dc.identifier.doi10.7892/boris.126085
dc.identifier.pmid29928168
dc.identifier.publisherDOI10.1159/000489900
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/63946
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofTransfusion medicine and hemotherapy
dc.relation.issn1660-3796
dc.relation.organizationDCD5A442C055E17DE0405C82790C4DE2
dc.subjectBlood safety Platelet concentrates Transfusion reaction Transfusion risks Transfusion-associated infections
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleNationwide Implementation of Pathogen Inactivation for All Platelet Concentrates in Switzerland.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage156
oaire.citation.issue3
oaire.citation.startPage151
oaire.citation.volume45
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationUniversitätsklinik für Hämatologie und Hämatologisches Zentrallabor
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unibe.date.licenseChanged2019-10-24 01:05:59
unibe.description.ispublishedpub
unibe.eprints.legacyId126085
unibe.journal.abbrevTitleTRANSFUS MED HEMOTH
unibe.refereedTRUE
unibe.subtype.articlejournal

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