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Predicting portal thrombosis in cirrhosis: A prospective study of clinical, ultrasonographic and hemostatic factors.

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dc.contributor.authorTuron, Fanny
dc.contributor.authorDriever, Ellen G
dc.contributor.authorBaiges, Anna
dc.contributor.authorCerda, Eira
dc.contributor.authorGarcía-Criado, Ángeles
dc.contributor.authorGilabert, Rosa
dc.contributor.authorBru, Concepció
dc.contributor.authorBerzigotti, Annalisa
dc.contributor.authorNuñez, Isabel
dc.contributor.authorOrts, Lara
dc.contributor.authorReverter, Juan Carlos
dc.contributor.authorMagaz, Marta
dc.contributor.authorCamprecios, Genis
dc.contributor.authorOlivas, Pol
dc.contributor.authorBetancourt-Sanchez, Fabian
dc.contributor.authorPerez-Campuzano, Valeria
dc.contributor.authorBlasi, Annabel
dc.contributor.authorSeijo, Susana
dc.contributor.authorReverter, Enric
dc.contributor.authorBosch Genover, Jaime
dc.contributor.authorBorràs, Roger
dc.contributor.authorHernandez-Gea, Virginia
dc.contributor.authorLisman, Ton
dc.contributor.authorGarcia-Pagan, Juan Carlos
dc.date.accessioned2024-10-05T06:51:02Z
dc.date.available2024-10-05T06:51:02Z
dc.date.issued2021-12
dc.description.abstractBACKGROUND & AIMS Portal vein thrombosis (PVT) is a relatively frequent event in patients with cirrhosis. While different risk factors for PVT have been reported, such as decreased portal blood flow velocity (PBFV) and parameters related with severity of portal hypertension, these are based on retrospective studies assessing only a discrete number of parameters. The aim of the current study was to evaluate the incidence and risks factors for non-tumoral PVT development in a large prospective cohort of patients with cirrhosis. METHODS We performed an exhaustive evaluation of clinical, biochemical, inflammatory and acquired/hereditary hemostatic profiles in 369 patients with cirrhosis without PVT who were prospectively followed-up. Doppler ultrasound was performed at baseline and every 6 months or whenever clinically indicated. PVT development was always confirmed by computed tomography. RESULTS Twenty-nine patients developed non-tumoral PVT, with an incidence of 1.6%, 6% and 8.4% at 1, 3 and 5 years, respectively. Low platelet count, PBFV <15 cm/sec and history of variceal bleeding were factors independently associated with a high PVT risk. No relationship between PVT development and any other clinical biochemical, inflammatory and acquired or hereditary hemostatic parameter was found. CONCLUSIONS In patients with cirrhosis, the factors predictive of PVT development were mainly those related to the severity of portal hypertension. Our results do not support the role of hemostatic alterations (inherited or acquired) and inflammatory markers in the prediction of PVT in patients with cirrhosis. LAY SUMMARY Patients with cirrhosis and more severe portal hypertension are at higher risk of non-tumoral portal vein thrombosis development. Acquired or inherited hemostatic disorders, as well as inflammatory status, do not seem to predict the development of portal vein thrombosis in patients with cirrhosis.
dc.description.numberOfPages10
dc.description.sponsorshipUniversitätsklinik für Viszerale Chirurgie und Medizin, Hepatologie
dc.identifier.doi10.48350/160193
dc.identifier.pmid34333101
dc.identifier.publisherDOI10.1016/j.jhep.2021.07.020
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/53754
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of hepatology
dc.relation.issn1600-0641
dc.relation.organizationDCD5A442BBC5E17DE0405C82790C4DE2
dc.subjectCirrhosis portal hypertension portal vein thrombosis
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titlePredicting portal thrombosis in cirrhosis: A prospective study of clinical, ultrasonographic and hemostatic factors.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage1376
oaire.citation.issue6
oaire.citation.startPage1367
oaire.citation.volume75
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