Transaminase-catalyzed continous synthesis of biogenic aldehydes

The physiological role of biogenic aldehydes such as DOPAL has been associated with cardiovascular and neurodegenerative disorders. The availability of these substrates is limited and robust synthetic methodologies would greatly facilitate further biological studies. Here we report on transaminase mediated single-step process in continuous mode which leads to excellent product yields (90-95%). Co-immoblization of the PLP cofactor eliminated the need of exogenous addition of this reagent without affecting the longevity of the system, delivering a truly self-sufficient process.