Feasibility and normal values of an integrated conductivity (Nanoduct™) sweat test system in healthy newborns.
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BORIS DOI
Publisher DOI
PubMed ID
28442278
Description
BACKGROUND
Nanoduct™ is a simple and practical sweat analysis system measuring conductivity in situ. It requires only three microlitres of sweat, making it especially applicable to newborns.
METHODS
We measured conductivity in 260 healthy term infants at the age of four days, and again at four weeks to determine the proportion of successful tests, test duration, and normal values for sweat conductivity in newborns.
RESULTS
Sufficient sweat was collected in 159/260 of four-day olds (61%), and in 225/239 of four-week olds (94%). Mean (sd) test duration was 27 (5) and 25 (5) min. Mean (sd, range) conductivity was 53mmol/l (16, 8-114) at age four days, and 36 (9, 12-64) at four weeks.
CONCLUSIONS
Determination of sweat conductivity using Nanoduct™ cannot be recommended for four-day old newborns. However, at the age of four weeks the success rate is high (94%), and conductivity values at that age are comparable to older healthy children.
Nanoduct™ is a simple and practical sweat analysis system measuring conductivity in situ. It requires only three microlitres of sweat, making it especially applicable to newborns.
METHODS
We measured conductivity in 260 healthy term infants at the age of four days, and again at four weeks to determine the proportion of successful tests, test duration, and normal values for sweat conductivity in newborns.
RESULTS
Sufficient sweat was collected in 159/260 of four-day olds (61%), and in 225/239 of four-week olds (94%). Mean (sd) test duration was 27 (5) and 25 (5) min. Mean (sd, range) conductivity was 53mmol/l (16, 8-114) at age four days, and 36 (9, 12-64) at four weeks.
CONCLUSIONS
Determination of sweat conductivity using Nanoduct™ cannot be recommended for four-day old newborns. However, at the age of four weeks the success rate is high (94%), and conductivity values at that age are comparable to older healthy children.
Date of Publication
2017-07
Publication Type
Article
Keyword(s)
Conductivity Cystic fibrosis Newborn screening Sweat test
Language(s)
en
Contributor(s)
Mazur, Agnieszka | |
Malzacher, Andreas | |
Hornung, René | |
Barben, Juerg |
Additional Credits
Series
Journal of cystic fibrosis
Publisher
Elsevier
ISSN
1569-1993
Access(Rights)
open.access