Publication:
A framework for testing the impact of co-infections on host gut microbiomes.

cris.virtual.author-orcid0000-0002-8314-8160
cris.virtualsource.author-orcidadbc8758-74ab-45a6-8266-2810c26cc44c
datacite.rightsopen.access
dc.contributor.authorSchmid, Dominik W
dc.contributor.authorFackelmann, Gloria
dc.contributor.authorUddin, Wasim
dc.contributor.authorRakotondranary, Jacques
dc.contributor.authorRatovonamana, Yedidya R
dc.contributor.authorMontero, B Karina
dc.contributor.authorGanzhorn, Jörg U
dc.contributor.authorSommer, Simone
dc.date.accessioned2024-10-11T16:59:55Z
dc.date.available2024-10-11T16:59:55Z
dc.date.issued2022-08-09
dc.description.abstractParasitic infections disturb gut microbial communities beyond their natural range of variation, possibly leading to dysbiosis. Yet it remains underappreciated that most infections are accompanied by one or more co-infections and their collective impact is largely unexplored. Here we developed a framework illustrating changes to the host gut microbiome following single infections, and build on it by describing the neutral, synergistic or antagonistic impacts on microbial α- and ß-diversity expected from co-infections. We tested the framework on microbiome data from a non-human primate population co-infected with helminths and Adenovirus, and matched patterns reported in published studies to the introduced framework. In this case study, α-diversity of co-infected Malagasy mouse lemurs (Microcebus griseorufus) did not differ in comparison with that of singly infected or uninfected individuals, even though community composition captured with ß-diversity metrices changed significantly. Explicitly, we record stochastic changes in dispersion, a sign of dysbiosis, following the Anna-Karenina principle rather than deterministic shifts in the microbial gut community. From the literature review and our case study, neutral and synergistic impacts emerged as common outcomes from co-infections, wherein both shifts and dispersion of microbial communities following co-infections were often more severe than after a single infection alone, but microbial α-diversity was not universally altered. Important functions of the microbiome may also suffer from such heavily altered, though no less species-rich microbial community. Lastly, we pose the hypothesis that the reshuffling of host-associated microbial communities due to the impact of various, often coinciding parasitic infections may become a source of novel or zoonotic diseases.
dc.description.sponsorshipInstitut für Infektionskrankheiten (IFIK)
dc.identifier.doi10.48350/171883
dc.identifier.pmid35945629
dc.identifier.publisherDOI10.1186/s42523-022-00198-5
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/86626
dc.language.isoen
dc.relation.ispartofAnimal microbiome
dc.relation.issn2524-4671
dc.relation.organizationDCD5A442BD12E17DE0405C82790C4DE2
dc.subjectCo-infections Disease ecology Dysbiosis Gut microbiome Helminths Non-human primate One health Parasites Virus Wildlife health
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleA framework for testing the impact of co-infections on host gut microbiomes.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.issue1
oaire.citation.startPage48
oaire.citation.volume4
oairecerif.author.affiliationInstitut für Infektionskrankheiten (IFIK)
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unibe.date.licenseChanged2022-08-11 08:49:18
unibe.description.ispublishedpub
unibe.eprints.legacyId171883
unibe.refereedtrue
unibe.subtype.articlereview

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