Publication: A framework for testing the impact of co-infections on host gut microbiomes.
cris.virtual.author-orcid | 0000-0002-8314-8160 | |
cris.virtualsource.author-orcid | adbc8758-74ab-45a6-8266-2810c26cc44c | |
datacite.rights | open.access | |
dc.contributor.author | Schmid, Dominik W | |
dc.contributor.author | Fackelmann, Gloria | |
dc.contributor.author | Uddin, Wasim | |
dc.contributor.author | Rakotondranary, Jacques | |
dc.contributor.author | Ratovonamana, Yedidya R | |
dc.contributor.author | Montero, B Karina | |
dc.contributor.author | Ganzhorn, Jörg U | |
dc.contributor.author | Sommer, Simone | |
dc.date.accessioned | 2024-10-11T16:59:55Z | |
dc.date.available | 2024-10-11T16:59:55Z | |
dc.date.issued | 2022-08-09 | |
dc.description.abstract | Parasitic infections disturb gut microbial communities beyond their natural range of variation, possibly leading to dysbiosis. Yet it remains underappreciated that most infections are accompanied by one or more co-infections and their collective impact is largely unexplored. Here we developed a framework illustrating changes to the host gut microbiome following single infections, and build on it by describing the neutral, synergistic or antagonistic impacts on microbial α- and ß-diversity expected from co-infections. We tested the framework on microbiome data from a non-human primate population co-infected with helminths and Adenovirus, and matched patterns reported in published studies to the introduced framework. In this case study, α-diversity of co-infected Malagasy mouse lemurs (Microcebus griseorufus) did not differ in comparison with that of singly infected or uninfected individuals, even though community composition captured with ß-diversity metrices changed significantly. Explicitly, we record stochastic changes in dispersion, a sign of dysbiosis, following the Anna-Karenina principle rather than deterministic shifts in the microbial gut community. From the literature review and our case study, neutral and synergistic impacts emerged as common outcomes from co-infections, wherein both shifts and dispersion of microbial communities following co-infections were often more severe than after a single infection alone, but microbial α-diversity was not universally altered. Important functions of the microbiome may also suffer from such heavily altered, though no less species-rich microbial community. Lastly, we pose the hypothesis that the reshuffling of host-associated microbial communities due to the impact of various, often coinciding parasitic infections may become a source of novel or zoonotic diseases. | |
dc.description.sponsorship | Institut für Infektionskrankheiten (IFIK) | |
dc.identifier.doi | 10.48350/171883 | |
dc.identifier.pmid | 35945629 | |
dc.identifier.publisherDOI | 10.1186/s42523-022-00198-5 | |
dc.identifier.uri | https://boris-portal.unibe.ch/handle/20.500.12422/86626 | |
dc.language.iso | en | |
dc.relation.ispartof | Animal microbiome | |
dc.relation.issn | 2524-4671 | |
dc.relation.organization | DCD5A442BD12E17DE0405C82790C4DE2 | |
dc.subject | Co-infections Disease ecology Dysbiosis Gut microbiome Helminths Non-human primate One health Parasites Virus Wildlife health | |
dc.subject.ddc | 500 - Science::570 - Life sciences; biology | |
dc.subject.ddc | 600 - Technology::610 - Medicine & health | |
dc.title | A framework for testing the impact of co-infections on host gut microbiomes. | |
dc.type | article | |
dspace.entity.type | Publication | |
dspace.file.type | text | |
oaire.citation.issue | 1 | |
oaire.citation.startPage | 48 | |
oaire.citation.volume | 4 | |
oairecerif.author.affiliation | Institut für Infektionskrankheiten (IFIK) | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.contributor.role | creator | |
unibe.date.licenseChanged | 2022-08-11 08:49:18 | |
unibe.description.ispublished | pub | |
unibe.eprints.legacyId | 171883 | |
unibe.refereed | true | |
unibe.subtype.article | review |
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