Publication:
Adult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish

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cris.virtual.author-orcid0000-0002-6702-1821
cris.virtual.author-orcid0000-0002-0905-6399
cris.virtualsource.author-orcid656eb86b-7300-4104-b1a3-39ce6d192705
cris.virtualsource.author-orcidd859b62c-b0dc-4c81-8824-f971a2ff907f
cris.virtualsource.author-orcida9488f23-8533-4d78-a7cd-5926a6b7c024
cris.virtualsource.author-orcid7eec37a1-7090-4eab-b47c-d7d6a031efaa
cris.virtualsource.author-orcid93933f3c-b464-47ce-a849-219b9ec985cb
cris.virtualsource.author-orcid385cd2e9-977e-4b46-a279-4061ecd4560e
cris.virtualsource.author-orcid79bc2168-817a-44ea-be31-b11af4269ff4
datacite.rightsopen.access
dc.contributor.authorSande Melon, Marcos
dc.contributor.authordos Santos Marques, Ines Joao
dc.contributor.authorGalardi-Castilla, María
dc.contributor.authorLanga Oliva, Javier
dc.contributor.authorPérez-López, María
dc.contributor.authorBotos, Marius-Alexandru
dc.contributor.authorSánchez-Iranzo, Héctor
dc.contributor.authorGuzmán-Martínez, Gabriela
dc.contributor.authorFerreira Francisco, David Miguel
dc.contributor.authorPavlinic, Dinko
dc.contributor.authorBenes, Vladimir
dc.contributor.authorBruggmann, Rémy
dc.contributor.authorMercader Huber, Nadia Isabel
dc.date.accessioned2024-10-28T17:38:26Z
dc.date.available2024-10-28T17:38:26Z
dc.date.issued2019
dc.description.abstractDuring heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of several cardiomyocyte populations bearing different capacity to replace lost myocardium. Here, using sox10 genetic fate mapping, we identify a subset of preexistent cardiomyocytes in the adult zebrafish heart with a distinct gene expression profile that expanded after cryoinjury. Genetic ablation of sox10+ cardiomyocytes impairs cardiac regeneration, revealing that these cells play a role in heart regeneration.
dc.description.numberOfPages14
dc.description.sponsorshipInstitut für Anatomie, Entwicklungsbiologie und Regeneration
dc.description.sponsorshipBioinformatik und computerbasierte Biologie
dc.description.sponsorshipInstitut für Anatomie
dc.identifier.doi10.7892/boris.135133
dc.identifier.pmid31644901
dc.identifier.publisherDOI10.1016/j.celrep.2019.09.041
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/183341
dc.language.isoen
dc.publisherCell Press
dc.relation.ispartofCell reports
dc.relation.issn2211-1247
dc.relation.organization5EBDFFD4994748B4B44FD17D5E463CFB
dc.relation.organizationDCD5A442BCD7E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BD6AE17DE0405C82790C4DE2
dc.relation.organizationEFA227295EB30F78E0405C82960C0615
dc.relation.schoolDCD5A442C27BE17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.subject.ddc500 - Science::570 - Life sciences; biology
dc.titleAdult sox10+ Cardiomyocytes Contribute to Myocardial Regeneration in the Zebrafish
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage1054
oaire.citation.issue4
oaire.citation.startPage1041
oaire.citation.volume29
oairecerif.author.affiliationInstitut für Anatomie, Entwicklungsbiologie und Regeneration
oairecerif.author.affiliationInstitut für Anatomie, Entwicklungsbiologie und Regeneration
oairecerif.author.affiliationInstitut für Anatomie, Entwicklungsbiologie und Regeneration
oairecerif.author.affiliationInstitut für Anatomie, Entwicklungsbiologie und Regeneration
oairecerif.author.affiliationBioinformatik und computerbasierte Biologie
oairecerif.author.affiliationBioinformatik und computerbasierte Biologie
oairecerif.author.affiliationInstitut für Anatomie
oairecerif.author.affiliation2Institut für Anatomie, Entwicklungsbiologie und Regeneration
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unibe.date.licenseChanged2019-12-10 13:50:45
unibe.description.ispublishedpub
unibe.eprints.legacyId135133
unibe.journal.abbrevTitleCell Reports
unibe.refereedtrue
unibe.subtype.articlejournal

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