Synchronized Oscillations of Arterial Oxygen Saturation, Cerebral Tissue Oxygenation and Heart Rate in Preterm Neonates: Investigation of Long-Term Measurements with Multiple Einstein's Cross Wavelet Analysis.
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BORIS DOI
Publisher DOI
PubMed ID
30178339
Description
BACKGROUND
In preterm neonates, the cardiovascular and cerebral vascular control is immature, making the brain vulnerable to an increased incidence of hypoxic and hyperoxic episodes.
AIM
The aim of the study was to apply the recently developed multiple Einstein's cross wavelet analysis (MECWA) to quantify the coupling of fluctuations of peripherally measured arterial oxygen saturation (SpO), cerebral tissue oxygen saturation (StO) and heart rate (HR).
METHODS
Two long-term measurements on preterm neonates with a gestational age at birth of 26.4 and 26.8 weeks and a postnatal age of 2.1 and 3.9 weeks were analyzed. MECWA was applied to SpO, StO and HR.
RESULTS
MECWA showed that the fluctuations of SpO, StO and HR were synchronized in the low-frequency range with periods of ~1 h and ~0.5 h. The amplitudes of the synchronization frequencies were dependent on the individual neonate.
DISCUSSION
MECWA is a useful novel tool to assess the coupling of physiological signals. The parameters determined by MECWA seem to be related to the chronobiological processes, as well as constant regulations of the cardiovascular and cerebral perfusion state.
CONCLUSION
MECWA was able to identify long-term synchronization of the cardiovascular and cerebral perfusion state in preterm neonates with periods of ~1 h and ~0.5 h.
In preterm neonates, the cardiovascular and cerebral vascular control is immature, making the brain vulnerable to an increased incidence of hypoxic and hyperoxic episodes.
AIM
The aim of the study was to apply the recently developed multiple Einstein's cross wavelet analysis (MECWA) to quantify the coupling of fluctuations of peripherally measured arterial oxygen saturation (SpO), cerebral tissue oxygen saturation (StO) and heart rate (HR).
METHODS
Two long-term measurements on preterm neonates with a gestational age at birth of 26.4 and 26.8 weeks and a postnatal age of 2.1 and 3.9 weeks were analyzed. MECWA was applied to SpO, StO and HR.
RESULTS
MECWA showed that the fluctuations of SpO, StO and HR were synchronized in the low-frequency range with periods of ~1 h and ~0.5 h. The amplitudes of the synchronization frequencies were dependent on the individual neonate.
DISCUSSION
MECWA is a useful novel tool to assess the coupling of physiological signals. The parameters determined by MECWA seem to be related to the chronobiological processes, as well as constant regulations of the cardiovascular and cerebral perfusion state.
CONCLUSION
MECWA was able to identify long-term synchronization of the cardiovascular and cerebral perfusion state in preterm neonates with periods of ~1 h and ~0.5 h.
Date of Publication
2018
Publication Type
Article
Subject(s)
Language(s)
en
Contributor(s)
Herrera, Graciela Velasco | |
Karen, Tanja | |
Isler, Helene | |
Ostojic, Daniel | |
Herrera, Victor Manuel Velasco | |
Wolf, Martin |
Series
Advances in experimental medicine and biology
Publisher
Springer
ISSN
0065-2598
Access(Rights)
restricted