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  3. Copeptin concentration in cord blood in infants with early-onset sepsis, chorioamnionitis and perinatal asphyxia
 

Copeptin concentration in cord blood in infants with early-onset sepsis, chorioamnionitis and perinatal asphyxia

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BORIS DOI
10.7892/boris.7630
Date of Publication
2011
Publication Type
Article
Division/Institute

Universitätsklinik fü...

Institut für Infektio...

Universitätsinstitut ...

Author
Schlapbach, Luregn Jan
Universitätsklinik für Kinderheilkunde
Frey, Stefanie
Bigler, Susanna
Institut für Infektionskrankheiten
Manh-Nhi, Chiem
Aebi, Christophorcid-logo
Universitätsklinik für Kinderheilkunde
Nelle, Mathias
Universitätsklinik für Kinderheilkunde
Nuoffer, Jean-Marcorcid-logo
Universitätsinstitut für Klinische Chemie (UKC)
Series
BMC pediatrics
ISSN or ISBN (if monograph)
1471-2431
Publisher
BioMed Central
Language
English
Publisher DOI
10.1186/1471-2431-11-38
PubMed ID
21595972
Description
Background

Vasopressin is one of the most important physiological stress and shock hormones. Copeptin, a stable vasopressin precursor, is a promising sepsis marker in adults. In contrast, its involvement in neonatal diseases remains unknown. The aim of this study was to establish copeptin concentrations in neonates of different stress states such as sepsis, chorioamnionitis and asphyxia.
Methods

Copeptin cord blood concentration was determined using the BRAHMS kryptor assay. Neonates with early-onset sepsis (EOS, n = 30), chorioamnionitis (n = 33) and asphyxia (n = 25) were compared to a control group of preterm and term (n = 155) neonates.
Results

Median copeptin concentration in cord blood was 36 pmol/l ranging from undetectable to 5498 pmol/l (IQR 7 - 419). Copeptin cord blood concentrations were non-normally distributed and increased with gestational age (p < 0.0001). Neonates born after vaginal compared to cesarean delivery had elevated copeptin levels (p < 0.0001). Copeptin correlated strongly with umbilical artery pH (Spearman's Rho -0.50, p < 0.0001), umbilical artery base excess (Rho -0.67, p < 0.0001) and with lactate at NICU admission (Rho 0.54, p < 0.0001). No difference was found when comparing copeptin cord blood concentrations between neonates with EOS and controls (multivariate p = 0.30). The highest copeptin concentrations were found in neonates with asphyxia (median 993 pmol/l). Receiver-operating-characteristic curve analysis showed that copeptin cord blood concentrations were strongly associated with asphyxia: the area under the curve resulted at 0.91 (95%-CI 0.87-0.96, p < 0.0001). A cut-off of 400 pmol/l had a sensitivity of 92% and a specifity of 82% for asphyxia as defined in this study.
Conclusions

Copeptin concentrations were strongly related to factors associated with perinatal stress such as birth acidosis, asphyxia and vaginal delivery. In contrast, copeptin appears to be unsuitable for the diagnosis of EOS.
Handle
https://boris-portal.unibe.ch/handle/20.500.12422/78081
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1471-2431-11-38.pdftextAdobe PDF1.83 MBAttribution (CC BY 4.0)publishedOpen
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