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Differential Diagnosis and Prognosis of Fetuses with Bilateral Enlarged, Hyperechogenic Kidneys: Renal Volume and Amniotic Fluid Volume with Advancing Gestation.

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cris.virtualsource.author-orcid413ecf13-bfd2-4275-8619-52996094963f
cris.virtualsource.author-orcide8c2a90f-361d-43fa-ae3d-c88c743043a2
cris.virtualsource.author-orcid8ff50d74-5129-48cb-bf1f-c05c0a57c460
cris.virtualsource.author-orcid64deb462-7a41-4564-9f46-29859cc7d5fa
cris.virtualsource.author-orcid835f493e-44b1-48a9-97bc-5b12c5c5b925
dc.contributor.authorMorr, Ann-Katrin
dc.contributor.authorMosimann, Beatrice
dc.contributor.authorTschumi, Sibylle
dc.contributor.authorSurbek, Daniel
dc.contributor.authorRaio, Luigi
dc.date.accessioned2024-10-07T05:33:53Z
dc.date.available2024-10-07T05:33:53Z
dc.date.issued2022-04
dc.description.abstractINTRODUCTION This study's objective was to identify prenatal criteria helping differential diagnosis of bilateral enlarged, hyperechogenic kidneys, especially looking at development of renal volume and amniotic fluid volume with increasing gestational age. METHOD Retrospective analysis (single-center database) of all bilateral enlarged, hyperechogenic kidneys between 2000-2018. Renal enlargement was defined as renal volume>90th percentile. Evaluation included development of renal and amniotic fluid volume during pregnancy and fetal outcome. RESULTS 23 cases fulfilled the inclusion criteria. 12 pregnancies were terminated. For 11 continued pregnancies, longitudinal information on amniotic fluid volume and renal volume were available. 4 cases with oligohydramnios showed a progressive reduction; 6 cases with normal/increased amniotic fluid volume remained stable; in 1 case amniotic fluid volume normalized from initially being oligohydramnios. Regarding renal volume, 4 cases showed exponential enlargement, 3 cases linear progression; in 2 cases renal volume stabilized after initial progression; 2 cases showed initial progression and secondary regression. 4 fetuses survived: 3 autosomal dominant polycystic kidney diseases, 1 Bardet-Biedl syndrome. CONCLUSION Progressive reduction of amniotic fluid volume with exponential increase of renal volume is highly suggestive for autosomal recessive polycystic kidney disease. Cases of autosomal dominant polycystic kidney disease show a linear progression of renal volume>90th percentile and mostly normal amniotic fluid volume.
dc.description.numberOfPages6
dc.description.sponsorshipUniversitätsklinik für Kinderheilkunde
dc.description.sponsorshipUniversitätsklinik für Frauenheilkunde
dc.identifier.doi10.48350/163044
dc.identifier.pmid34492706
dc.identifier.publisherDOI10.1055/a-1586-5493
dc.identifier.urihttps://boris-portal.unibe.ch/handle/20.500.12422/58895
dc.language.isoen
dc.publisherThieme
dc.relation.ispartofZeitschrift für Geburtshilfe und Neonatologie
dc.relation.issn0948-2393
dc.relation.organizationDCD5A442BADAE17DE0405C82790C4DE2
dc.relation.organizationDCD5A442BB25E17DE0405C82790C4DE2
dc.relation.organizationDCD5A442C056E17DE0405C82790C4DE2
dc.subject.ddc600 - Technology::610 - Medicine & health
dc.titleDifferential Diagnosis and Prognosis of Fetuses with Bilateral Enlarged, Hyperechogenic Kidneys: Renal Volume and Amniotic Fluid Volume with Advancing Gestation.
dc.typearticle
dspace.entity.typePublication
dspace.file.typetext
oaire.citation.endPage103
oaire.citation.issue2
oaire.citation.startPage98
oaire.citation.volume226
oairecerif.author.affiliationUniversitätsklinik für Frauenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Frauenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Kinderheilkunde
oairecerif.author.affiliationUniversitätsklinik für Frauenheilkunde
oairecerif.author.affiliationUniversitätsklinik für Frauenheilkunde
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unibe.date.licenseChanged2021-12-27 12:44:11
unibe.description.ispublishedpub
unibe.eprints.legacyId163044
unibe.journal.abbrevTitleZGN
unibe.refereedTRUE
unibe.subtype.articlejournal

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